Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5657403..5657983 Replicon chromosome
Accession NZ_CP062253
Organism Pseudomonas gozinkensis strain IzPS32d

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IHQ43_RS25200 Protein ID WP_192562476.1
Coordinates 5657403..5657681 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHQ43_RS25205 Protein ID WP_045121630.1
Coordinates 5657696..5657983 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHQ43_RS25180 5652965..5653132 - 168 WP_007950992.1 DUF2474 domain-containing protein -
IHQ43_RS25185 5653210..5654217 - 1008 WP_192562473.1 cytochrome d ubiquinol oxidase subunit II -
IHQ43_RS25190 5654221..5655657 - 1437 WP_192562474.1 cytochrome ubiquinol oxidase subunit I -
IHQ43_RS25195 5656058..5657296 + 1239 WP_192562475.1 MFS transporter -
IHQ43_RS25200 5657403..5657681 + 279 WP_192562476.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHQ43_RS25205 5657696..5657983 + 288 WP_045121630.1 HigA family addiction module antidote protein Antitoxin
IHQ43_RS25210 5657989..5658540 - 552 WP_192562477.1 DJ-1/PfpI family protein -
IHQ43_RS25215 5658608..5659057 - 450 WP_192562478.1 DUF4879 domain-containing protein -
IHQ43_RS25220 5659278..5660573 + 1296 WP_064599583.1 NCS2 family permease -
IHQ43_RS25225 5660570..5661649 + 1080 WP_192562479.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
IHQ43_RS25230 5661705..5662151 - 447 WP_192562480.1 hypothetical protein -
IHQ43_RS25235 5662148..5662576 - 429 WP_192565060.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10719.30 Da        Isoelectric Point: 8.9401

>T174170 WP_192562476.1 NZ_CP062253:5657403-5657681 [Pseudomonas gozinkensis]
MIKSFQHKGLRGFYETGSTRGIRADHAKRLSRMLQFMDRAAVPGDLDLPGWRMHPLKGELCEYWSLSVSGNWRVIFRFAG
SDIELIDYLDYH

Download         Length: 279 bp

>T174170 NZ_CP080564:c2160179-2160075 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10542.17 Da        Isoelectric Point: 6.9219

>AT174170 WP_045121630.1 NZ_CP062253:5657696-5657983 [Pseudomonas gozinkensis]
MPMHNPPHPGETLLMDVLPELGISVTELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARMWLGVQTDYDLWQA
EHREQPAIQPIAAHA

Download         Length: 288 bp

>AT174170 NZ_CP080564:2159982-2160020 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References