Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 334110..334714 Replicon chromosome
Accession NZ_CP062253
Organism Pseudomonas gozinkensis strain IzPS32d

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IHQ43_RS01430 Protein ID WP_115076186.1
Coordinates 334400..334714 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHQ43_RS01425 Protein ID WP_192563128.1
Coordinates 334110..334397 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHQ43_RS01400 329145..329924 - 780 WP_192563124.1 EAL domain-containing protein -
IHQ43_RS01405 330041..330448 + 408 WP_192563125.1 RNA-binding protein -
IHQ43_RS01410 330514..331314 - 801 WP_192563126.1 phosphatase PAP2 family protein -
IHQ43_RS01415 331419..332321 + 903 WP_085608616.1 Hsp33 family molecular chaperone HslO -
IHQ43_RS01420 332503..334044 + 1542 WP_192563127.1 phosphoenolpyruvate carboxykinase -
IHQ43_RS01425 334110..334397 - 288 WP_192563128.1 helix-turn-helix domain-containing protein Antitoxin
IHQ43_RS01430 334400..334714 - 315 WP_115076186.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHQ43_RS01435 334826..335125 - 300 WP_115076187.1 hypothetical protein -
IHQ43_RS01440 335676..336803 - 1128 WP_192563129.1 hypothetical protein -
IHQ43_RS01445 336906..337187 - 282 WP_192563130.1 hypothetical protein -
IHQ43_RS01450 337492..337995 + 504 WP_192563131.1 polysaccharide deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11833.73 Da        Isoelectric Point: 10.3534

>T174163 WP_115076186.1 NZ_CP062253:c334714-334400 [Pseudomonas gozinkensis]
MIFVETRIFTRRVKELLDDDTYAAFQKQLVVSPSIGDVIEGTGGIRKTRIAAKGHGKRGGARVIYYHFVSASQIGLLMIY
PKNEQHDLSSDERKALKVLIEKWR

Download         Length: 315 bp

>T174163 NZ_CP080562:c2661775-2661509 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10705.28 Da        Isoelectric Point: 7.4052

>AT174163 WP_192563128.1 NZ_CP062253:c334397-334110 [Pseudomonas gozinkensis]
MSKFFDELMESVQEMDEIVRGGRTPSREFHVDALQVKEIRKATGLTQTKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAH

Download         Length: 288 bp

>AT174163 NZ_CP080562:c2662032-2661775 [Staphylococcus aureus]
ATGATTATCACTAGTCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References