Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5678900..5679480 Replicon chromosome
Accession NZ_CP062252
Organism Pseudomonas allokribbensis strain IzPS23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF199_RS26065 Protein ID WP_085697557.1
Coordinates 5678900..5679178 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF199_RS26070 Protein ID WP_045121630.1
Coordinates 5679193..5679480 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF199_RS26045 5674481..5674648 - 168 WP_007950992.1 DUF2474 domain-containing protein -
IF199_RS26050 5674706..5675713 - 1008 WP_085697554.1 cytochrome d ubiquinol oxidase subunit II -
IF199_RS26055 5675717..5677153 - 1437 WP_192559049.1 cytochrome ubiquinol oxidase subunit I -
IF199_RS26060 5677554..5678792 + 1239 WP_096820837.1 MFS transporter -
IF199_RS26065 5678900..5679178 + 279 WP_085697557.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IF199_RS26070 5679193..5679480 + 288 WP_045121630.1 HigA family addiction module antidote protein Antitoxin
IF199_RS26075 5679486..5680037 - 552 WP_192559050.1 DJ-1/PfpI family protein -
IF199_RS26080 5680105..5680554 - 450 WP_192559051.1 DUF4879 domain-containing protein -
IF199_RS26085 5680775..5682070 + 1296 WP_096820834.1 NCS2 family permease -
IF199_RS26090 5682067..5683146 + 1080 WP_192559052.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
IF199_RS26095 5683202..5683648 - 447 WP_192559053.1 hypothetical protein -
IF199_RS26100 5683645..5684073 - 429 WP_192559054.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10687.24 Da        Isoelectric Point: 8.9401

>T174162 WP_085697557.1 NZ_CP062252:5678900-5679178 [Pseudomonas allokribbensis]
MIKSFQHKGLRGFYETGSTRGIRADHAKRLSRMLQFMDRAAVPGDLDLPGWRLHPLKGELCEYWSLSVSGNWRVIFRFAG
SDIELVDYLDYH

Download         Length: 279 bp

>T174162 NZ_CP080562:c2605078-2604812 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10542.17 Da        Isoelectric Point: 6.9219

>AT174162 WP_045121630.1 NZ_CP062252:5679193-5679480 [Pseudomonas allokribbensis]
MPMHNPPHPGETLLMDVLPELGISVTELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARMWLGVQTDYDLWQA
EHREQPAIQPIAAHA

Download         Length: 288 bp

>AT174162 NZ_CP080562:c2605329-2605078 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References