Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 5400667..5401322 Replicon chromosome
Accession NZ_CP062252
Organism Pseudomonas allokribbensis strain IzPS23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF199_RS24730 Protein ID WP_096822808.1
Coordinates 5400978..5401322 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF199_RS24725 Protein ID WP_096822807.1
Coordinates 5400667..5400981 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF199_RS24700 5396177..5396695 - 519 WP_192558940.1 peptide-methionine (R)-S-oxide reductase MsrB -
IF199_RS24705 5396847..5397563 + 717 WP_192558941.1 response regulator transcription factor -
IF199_RS24710 5397560..5399080 + 1521 WP_192558942.1 HAMP domain-containing histidine kinase -
IF199_RS24715 5399201..5399905 + 705 WP_192558943.1 hypothetical protein -
IF199_RS24720 5399976..5400467 - 492 WP_085709372.1 RidA family protein -
IF199_RS24725 5400667..5400981 - 315 WP_096822807.1 helix-turn-helix domain-containing protein Antitoxin
IF199_RS24730 5400978..5401322 - 345 WP_096822808.1 toxin Toxin
IF199_RS24735 5401448..5402335 - 888 WP_085668163.1 heme o synthase -
IF199_RS24740 5402346..5402681 - 336 WP_065261339.1 cytochrome o ubiquinol oxidase subunit IV -
IF199_RS24745 5402681..5403307 - 627 WP_007956720.1 cytochrome o ubiquinol oxidase subunit III -
IF199_RS24750 5403311..5405341 - 2031 WP_096822810.1 cytochrome o ubiquinol oxidase subunit I -
IF199_RS24755 5405345..5406286 - 942 WP_096822811.1 ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-94)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13416.22 Da        Isoelectric Point: 9.3030

>T174161 WP_096822808.1 NZ_CP062252:c5401322-5400978 [Pseudomonas allokribbensis]
MRTIFFETTLFTANLGHYLTDDEYRELQTYMQSNPHAGDVMPRTGGFRKLRWADARRGKGRRGGLRVIYYWLMNDGQFWM
FAIYDKDELENLTADQERALKGAIEKELKTRGTP

Download         Length: 345 bp

>T174161 NZ_CP080562:c2244120-2243911 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11873.80 Da        Isoelectric Point: 10.3048

>AT174161 WP_096822807.1 NZ_CP062252:c5400981-5400667 [Pseudomonas allokribbensis]
MKKRDLFAELMQGVDEMAAQREGKITLRNTTLEDKPAPEVAAQEIVALREKLHMSQAVFARRIRTSPSTLRNWEQEKSKP
NAQAALLIRLVEKFPDMVERLSAV

Download         Length: 315 bp

>AT174161 NZ_CP080562:c2244425-2244132 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References