Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 5178796..5179451 Replicon chromosome
Accession NZ_CP062251
Organism Pseudomonas sp. IzPS59

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF189_RS23160 Protein ID WP_096822808.1
Coordinates 5179107..5179451 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF189_RS23155 Protein ID WP_007956715.1
Coordinates 5178796..5179110 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF189_RS23130 5174307..5174825 - 519 WP_134828030.1 peptide-methionine (R)-S-oxide reductase MsrB -
IF189_RS23135 5174977..5175693 + 717 WP_192552329.1 response regulator transcription factor -
IF189_RS23140 5175690..5177210 + 1521 WP_192552330.1 HAMP domain-containing histidine kinase -
IF189_RS23145 5177331..5178035 + 705 WP_192552331.1 hypothetical protein -
IF189_RS23150 5178105..5178596 - 492 WP_192552332.1 RidA family protein -
IF189_RS23155 5178796..5179110 - 315 WP_007956715.1 helix-turn-helix domain-containing protein Antitoxin
IF189_RS23160 5179107..5179451 - 345 WP_096822808.1 toxin Toxin
IF189_RS23165 5179578..5180465 - 888 WP_039765651.1 heme o synthase -
IF189_RS23170 5180476..5180811 - 336 WP_085709371.1 cytochrome o ubiquinol oxidase subunit IV -
IF189_RS23175 5180811..5181437 - 627 WP_007956720.1 cytochrome o ubiquinol oxidase subunit III -
IF189_RS23180 5181441..5183471 - 2031 WP_085701769.1 cytochrome o ubiquinol oxidase subunit I -
IF189_RS23185 5183475..5184416 - 942 WP_065261342.1 ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-94)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13416.22 Da        Isoelectric Point: 9.3030

>T174153 WP_096822808.1 NZ_CP062251:c5179451-5179107 [Pseudomonas sp. IzPS59]
MRTIFFETTLFTANLGHYLTDDEYRELQTYMQSNPHAGDVMPRTGGFRKLRWADARRGKGRRGGLRVIYYWLMNDGQFWM
FAIYDKDELENLTADQERALKGAIEKELKTRGTP

Download         Length: 345 bp

>T174153 NZ_CP080560:c2250792-2250430 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11859.77 Da        Isoelectric Point: 10.3048

>AT174153 WP_007956715.1 NZ_CP062251:c5179110-5178796 [Pseudomonas sp. IzPS59]
MKKRDLFAELMQGVDEMAAQREGKITLRNTTLEDKPAPEVGAQEIVALREKLHMSQAVFARRIRTSPSTLRNWEQEKSKP
NAQAALLIRLVEKFPDMVERLSAV

Download         Length: 315 bp

>AT174153 NZ_CP080560:c2250959-2250789 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References