174091

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3162409..3163102 Replicon chromosome
Accession NZ_CP062249
Organism Escherichia coli strain AML002_ev01

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IHN46_RS15350 Protein ID WP_000415584.1
Coordinates 3162806..3163102 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IHN46_RS15345 Protein ID WP_000650107.1
Coordinates 3162409..3162804 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHN46_RS15335 3158273..3160531 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
IHN46_RS15340 3160669..3162276 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IHN46_RS15345 3162409..3162804 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IHN46_RS15350 3162806..3163102 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IHN46_RS15355 3163307..3163789 - 483 WP_000183505.1 transcriptional regulator -
IHN46_RS15360 3163842..3164234 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IHN46_RS15365 3164386..3165045 + 660 WP_001221495.1 two-component system response regulator QseB -
IHN46_RS15370 3165042..3166391 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IHN46_RS15375 3166437..3166769 - 333 WP_000917684.1 DUF2645 family protein -
IHN46_RS15380 3167088..3167669 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IHN46_RS15385 3167700..3168014 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T174091 WP_000415584.1 NZ_CP062249:c3163102-3162806 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T174091 NZ_CP080536:c2276322-2275891 [Acidithiobacillus ferriphilus]
ATGATCTTCTTGCTCGATGTAAACGTGCTGATTGCGCTCATCGACCCCATGCATGTTCAGCATGATATGGCTCATGAATG
GTTTGCAGCCCATGGGCAACCCGCATGGGCTACCTGTCCCTTAACAGAGAATGCTGTGCTGCGCATTGTGGGTCATCCGC
GTTATCCAAATTCGCCAGGCACACCAGCGGCAGTGGCACCCCTGATCCAGGGATTGCGCGCGTCACCTGGCCATGTTTTT
TGGCCAGATGACATCAGCCTACTGGATGTCGATCATATCGACGCATCGCGTCTGCTGACTTCTGGTCAGATTACCGATAG
CTACCTCTTGGCGCTGGCCTGCGCCCATGAGGGCCAACTGGCAACCTTCGACCATCGCTTAGTGACCAATGCCGTGCGCA
ACGGTTTGCAATGCATAAACAAAATTAGGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT174091 WP_000650107.1 NZ_CP062249:c3162804-3162409 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT174091 NZ_CP080536:c2276555-2276322 [Acidithiobacillus ferriphilus]
ATGCGTACCACACTGGCGATTGATGATGACGTACTGGCGGCGGCGAAAGGGCTGGCGGATCGACAGCATAAGCCTGTAGG
TGCCGTTGTTTCAGCACTTTTGCGGCAGGCTCTGCAATCACAAAACACCTCTGGTGGTCATTCACGTAATGGGATTCCCT
TGCTGCCGGTGCGCCCGGATGCACTCCCGGCGACTCTGGAAATAGTGAATCAGTTGCGCGACGAATTGCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References