Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2083891..2084393 | Replicon | chromosome |
Accession | NZ_CP062249 | ||
Organism | Escherichia coli strain AML002_ev01 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | IHN46_RS10325 | Protein ID | WP_000767829.1 |
Coordinates | 2083891..2084145 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | IHN46_RS10330 | Protein ID | WP_001259255.1 |
Coordinates | 2084142..2084393 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IHN46_RS10295 | 2078906..2079133 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
IHN46_RS10300 | 2079147..2080205 | - | 1059 | WP_000492339.1 | transport protein YeeE | - |
IHN46_RS10305 | 2080384..2081742 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
IHN46_RS10310 | 2081732..2081794 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
IHN46_RS10315 | 2082009..2082938 | - | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
IHN46_RS10320 | 2082984..2083808 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
IHN46_RS10325 | 2083891..2084145 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
IHN46_RS10330 | 2084142..2084393 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
IHN46_RS10335 | 2084676..2084726 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
IHN46_RS10340 | 2084872..2085771 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
IHN46_RS10345 | 2085777..2087081 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
IHN46_RS10350 | 2087078..2088148 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
IHN46_RS10355 | 2088148..2089215 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T174086 WP_000767829.1 NZ_CP062249:c2084145-2083891 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T174086 NZ_CP080536:926648-926929 [Acidithiobacillus ferriphilus]
ATGATTCAAACATTCGCCAACACTGAAACCGAAGGCTTTTTCGTTACAGGTAAATCGCGTCGTTTACCTTCGGAAATTCT
CAAGCGTGCAGCCATGCGTCTCAATCAGTTGCATGCCGCTACAGAGTTGAATGATCTACATTTGCCACCCTCTAATCACT
TGGAGGCTCTTTCAGGTAATCGCATTGGTCAATGGAGTATACGTATAAACCAACAGTGGCGTGTCTGTTTCAAGTTTGAA
AATGGTGACGCATTTAATGTCGAAATAGTGGATTACCACTAG
ATGATTCAAACATTCGCCAACACTGAAACCGAAGGCTTTTTCGTTACAGGTAAATCGCGTCGTTTACCTTCGGAAATTCT
CAAGCGTGCAGCCATGCGTCTCAATCAGTTGCATGCCGCTACAGAGTTGAATGATCTACATTTGCCACCCTCTAATCACT
TGGAGGCTCTTTCAGGTAATCGCATTGGTCAATGGAGTATACGTATAAACCAACAGTGGCGTGTCTGTTTCAAGTTTGAA
AATGGTGACGCATTTAATGTCGAAATAGTGGATTACCACTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT174086 WP_001259255.1 NZ_CP062249:c2084393-2084142 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT174086 NZ_CP080536:926940-927236 [Acidithiobacillus ferriphilus]
ATGATCTACAATGGTTTAACACCTATCCATCCCGGCGAGTACCTCGCCGAGCTCCTTGAAGAGCTTCATATCTCTCAAGC
GTTGTTCGCTCGTACCATTGGTGTGTCGCCCATGCGCATTTCCCATATCGTTAAAGGCAAGCGCCCTGTTACGGCTGAAC
TAGCATTGCTGTTTGCAAAAGCTTTTGAGCAAACTCCACAGTATTGGCTCAATTTACAAGCCAGCTATGATCTAAAAACT
GCTGAGAAAAGCATCGCCAATCGTCTCTTCTCCATTCATAGCTTGGCCCATGCTTAA
ATGATCTACAATGGTTTAACACCTATCCATCCCGGCGAGTACCTCGCCGAGCTCCTTGAAGAGCTTCATATCTCTCAAGC
GTTGTTCGCTCGTACCATTGGTGTGTCGCCCATGCGCATTTCCCATATCGTTAAAGGCAAGCGCCCTGTTACGGCTGAAC
TAGCATTGCTGTTTGCAAAAGCTTTTGAGCAAACTCCACAGTATTGGCTCAATTTACAAGCCAGCTATGATCTAAAAACT
GCTGAGAAAAGCATCGCCAATCGTCTCTTCTCCATTCATAGCTTGGCCCATGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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