Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 1586310..1587898 | Replicon | chromosome |
Accession | NZ_CP062249 | ||
Organism | Escherichia coli strain AML002_ev01 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | S1ELM3 |
Locus tag | IHN46_RS07725 | Protein ID | WP_001125439.1 |
Coordinates | 1586310..1587632 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | IHN46_RS07730 | Protein ID | WP_001301023.1 |
Coordinates | 1587632..1587898 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IHN46_RS07700 | 1582276..1583190 | - | 915 | WP_000520676.1 | fimbrial protein | - |
IHN46_RS07705 | 1583249..1583752 | - | 504 | WP_000825452.1 | type 1 fimbrial protein | - |
IHN46_RS07710 | 1583765..1584295 | - | 531 | WP_000876763.1 | type 1 fimbrial protein | - |
IHN46_RS07715 | 1584309..1585535 | - | 1227 | Protein_1506 | fimbrial biogenesis outer membrane usher protein | - |
IHN46_RS07720 | 1585790..1585998 | - | 209 | Protein_1507 | helix-turn-helix transcriptional regulator | - |
IHN46_RS07725 | 1586310..1587632 | - | 1323 | WP_001125439.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
IHN46_RS07730 | 1587632..1587898 | - | 267 | WP_001301023.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
IHN46_RS07735 | 1588121..1589521 | - | 1401 | WP_001083595.1 | autotransporter outer membrane beta-barrel domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1576298..1587898 | 11600 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49275.82 Da Isoelectric Point: 8.2482
>T174075 WP_001125439.1 NZ_CP062249:c1587632-1586310 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
Download Length: 1323 bp
>T174075 NZ_CP080530:c311029-310643 [Mesorhizobium sp. AR02]
ATGGTGATCGACACTTCAGCCATTGTGGCGATCCTGCGTAGCGAACCCGAGGCAGCAAGGCTTGAACAAGCCCTTGTCTC
CGATCCAATCCGTCTGGTTCCGGCGACTTGTGTGCTCGAAGCACGCATGGTGCTGGTCAGCAGGCGCGGCGAACACGCAT
TGGCGGAGATCGATCTCTGGCTTCACAAGATCGGGGCCAACATCATTCCCGTTGATTCCGAATTGGTTGATCTGGCCACC
CAAGCTTGGCTCTCCTACGGCAAGGGCCGTCATCCTGCCGCCTTGAACTTTGCCGATTGCTTCTCCTACGCTTTGGCAAA
GCGTGCCGATGAGCCGCTGCTTTTCATCGGCAAGGACTTCTCCCAGACGGATATCGAGGCGGCATAA
ATGGTGATCGACACTTCAGCCATTGTGGCGATCCTGCGTAGCGAACCCGAGGCAGCAAGGCTTGAACAAGCCCTTGTCTC
CGATCCAATCCGTCTGGTTCCGGCGACTTGTGTGCTCGAAGCACGCATGGTGCTGGTCAGCAGGCGCGGCGAACACGCAT
TGGCGGAGATCGATCTCTGGCTTCACAAGATCGGGGCCAACATCATTCCCGTTGATTCCGAATTGGTTGATCTGGCCACC
CAAGCTTGGCTCTCCTACGGCAAGGGCCGTCATCCTGCCGCCTTGAACTTTGCCGATTGCTTCTCCTACGCTTTGGCAAA
GCGTGCCGATGAGCCGCTGCTTTTCATCGGCAAGGACTTCTCCCAGACGGATATCGAGGCGGCATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10016.38 Da Isoelectric Point: 6.2267
>AT174075 WP_001301023.1 NZ_CP062249:c1587898-1587632 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
Download Length: 267 bp
>AT174075 NZ_CP080530:c311286-311029 [Mesorhizobium sp. AR02]
GTGTCCCTCAATATCAAAAATCCGGCAACCGTCGCGCTGGCCGACGAGCTCGCGCGCCGCCAGGGTATCAGCAAGACGGC
GGCTATTCATCAGGCCTTGAGCGAGCGCCTGCATCGCATGGGTTTCGGTGACACTGCGCAGGAGCGCCTGCTCGCGGAGC
TGCGCTCAATCCGGGAGAGACTGGCGCGGTTGCCTGAACGGGATAATCGCACTGACGAGGAGATCATCGGCTACGACGAA
CACGGAATTCCCAACTGA
GTGTCCCTCAATATCAAAAATCCGGCAACCGTCGCGCTGGCCGACGAGCTCGCGCGCCGCCAGGGTATCAGCAAGACGGC
GGCTATTCATCAGGCCTTGAGCGAGCGCCTGCATCGCATGGGTTTCGGTGACACTGCGCAGGAGCGCCTGCTCGCGGAGC
TGCGCTCAATCCGGGAGAGACTGGCGCGGTTGCCTGAACGGGATAATCGCACTGACGAGGAGATCATCGGCTACGACGAA
CACGGAATTCCCAACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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