Detailed information of TA system TA173922

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3693339..3693561
• Replicon: chromosome
• Accession: NZ_CP062245
• Organism: Escherichia coli strain AML003_ev01

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: IHN50_RS17920
• Protein ID: WP_000141634.1
• Coordinates: 3693339..3693446 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3693495..3693561 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHN50_RS17895	3688592..3689344	-	753	Protein_3495	cellulose biosynthesis protein BcsQ	-
IHN50_RS17900	3689356..3689544	-	189	WP_001063318.1	YhjR family protein	-
IHN50_RS17905	3689817..3691388	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
IHN50_RS17910	3691385..3691576	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
IHN50_RS17915	3691573..3693252	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
IHN50_RS17920	3693339..3693446	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3693495..3693561	+	67	-	-	Antitoxin
IHN50_RS17925	3693922..3695193	+	1272	WP_001295225.1	transporter	-
IHN50_RS17930	3695223..3696227	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
IHN50_RS17935	3696224..3697207	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
IHN50_RS17940	3697218..3698120	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T173922 WP_000141634.1 NZ_CP062245:c3693446-3693339 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T173922 NZ_CP080400:714695-715126 [Dickeya fangzhongdai]
GTGGCCCAGTGGCAATGTGATTTGCGTGTATCCTGGCGCATGCAGTTGTTTTCTCTGCTGACGCACGGGTTCCTGGTGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACCGGCAAAGGGCA
TCAGCGCCTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAATGGCGGCTGTTGCGCCAGCTGTTGCAGCAGCACCCGC
TGCAGGGAACTGAATCTTCCCGCCATCATTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT173922 NZ_CP062245:3693495-3693561 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin