Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2082691..2083193 | Replicon | chromosome |
Accession | NZ_CP062245 | ||
Organism | Escherichia coli strain AML003_ev01 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | IHN50_RS10315 | Protein ID | WP_000767829.1 |
Coordinates | 2082691..2082945 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | IHN50_RS10320 | Protein ID | WP_001259255.1 |
Coordinates | 2082942..2083193 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IHN50_RS10285 | 2077706..2077933 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
IHN50_RS10290 | 2077947..2079005 | - | 1059 | WP_000492339.1 | transport protein YeeE | - |
IHN50_RS10295 | 2079184..2080542 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
IHN50_RS10300 | 2080532..2080594 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
IHN50_RS10305 | 2080809..2081738 | - | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
IHN50_RS10310 | 2081784..2082608 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
IHN50_RS10315 | 2082691..2082945 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
IHN50_RS10320 | 2082942..2083193 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
IHN50_RS10325 | 2083476..2083526 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
IHN50_RS10330 | 2083672..2084571 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
IHN50_RS10335 | 2084577..2085881 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
IHN50_RS10340 | 2085878..2086948 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
IHN50_RS10345 | 2086948..2088015 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T173914 WP_000767829.1 NZ_CP062245:c2082945-2082691 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T173914 NZ_CP080383:2315045-2315290 [Cryobacterium sp. PAMC25264]
GTGGCAATTACAGCCTCACAAGCAAGGGCTCAGTTGTTCCCGTTGATCGAAAAGGTCAATGAGGACCACATGCCCATCGA
AATCGTCTCCAAGAAGGGCAGCGCGGTTCTCATGTCGCTGGCTGACTACGAGGCACTCGAAGAAACCGCCTACCTGCTGC
GTTCCCCCGCTAACGCGGCGCACCTGCTCGAAAGCATCGCGCAGCACCGGGCCGGCACGGCGAGCGTTCGTCCCCTGGCC
GAGTGA
GTGGCAATTACAGCCTCACAAGCAAGGGCTCAGTTGTTCCCGTTGATCGAAAAGGTCAATGAGGACCACATGCCCATCGA
AATCGTCTCCAAGAAGGGCAGCGCGGTTCTCATGTCGCTGGCTGACTACGAGGCACTCGAAGAAACCGCCTACCTGCTGC
GTTCCCCCGCTAACGCGGCGCACCTGCTCGAAAGCATCGCGCAGCACCGGGCCGGCACGGCGAGCGTTCGTCCCCTGGCC
GAGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT173914 WP_001259255.1 NZ_CP062245:c2083193-2082942 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT173914 NZ_CP080383:2315287-2315541 [Cryobacterium sp. PAMC25264]
GTGATAATCGCGTTCACGGATGCCGGCTGGGACGACTATCAATATTGGGTCACCACTGACCGGACGATGGTGAAACGCAT
CAACAAGCTCATCGCCGACGTGCAACGCACCCCGTTCACCGGCATCGGTAAACCCGAAGCGCTCAAGCATCAACTCGCCG
GGTACTGGTCCCGCCGCATCACCGATGAACACCGGCTGGTGTACACGGTGGAGCAGAACGAGATCGTCATCATCGCCGCT
CGGCATCACTACTAA
GTGATAATCGCGTTCACGGATGCCGGCTGGGACGACTATCAATATTGGGTCACCACTGACCGGACGATGGTGAAACGCAT
CAACAAGCTCATCGCCGACGTGCAACGCACCCCGTTCACCGGCATCGGTAAACCCGAAGCGCTCAAGCATCAACTCGCCG
GGTACTGGTCCCGCCGCATCACCGATGAACACCGGCTGGTGTACACGGTGGAGCAGAACGAGATCGTCATCATCGCCGCT
CGGCATCACTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|