Detailed information of TA system TA173836

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3694547..3694769
• Replicon: chromosome
• Accession: NZ_CP062243
• Organism: Escherichia coli strain AML003_ev03

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: IHN52_RS17925
• Protein ID: WP_000141634.1
• Coordinates: 3694547..3694654 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3694703..3694769 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHN52_RS17900	3689800..3690552	-	753	Protein_3496	cellulose biosynthesis protein BcsQ	-
IHN52_RS17905	3690564..3690752	-	189	WP_001063318.1	YhjR family protein	-
IHN52_RS17910	3691025..3692596	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
IHN52_RS17915	3692593..3692784	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
IHN52_RS17920	3692781..3694460	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
IHN52_RS17925	3694547..3694654	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3694703..3694769	+	67	-	-	Antitoxin
IHN52_RS17930	3695130..3696401	+	1272	WP_001295225.1	transporter	-
IHN52_RS17935	3696431..3697435	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
IHN52_RS17940	3697432..3698415	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
IHN52_RS17945	3698426..3699328	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T173836 WP_000141634.1 NZ_CP062243:c3694654-3694547 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T173836 NZ_CP080346:798507-798917 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT173836 NZ_CP062243:3694703-3694769 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin