Detailed information of TA system TA173707

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3694539..3694761
• Replicon: chromosome
• Accession: NZ_CP062240
• Organism: Escherichia coli strain AML001_ev02

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: IHN55_RS17925
• Protein ID: WP_000141634.1
• Coordinates: 3694539..3694646 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3694695..3694761 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHN55_RS17900	3689792..3690544	-	753	Protein_3496	cellulose biosynthesis protein BcsQ	-
IHN55_RS17905	3690556..3690744	-	189	WP_001063318.1	YhjR family protein	-
IHN55_RS17910	3691017..3692588	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
IHN55_RS17915	3692585..3692776	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
IHN55_RS17920	3692773..3694452	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
IHN55_RS17925	3694539..3694646	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3694695..3694761	+	67	-	-	Antitoxin
IHN55_RS17930	3695122..3696393	+	1272	WP_001295225.1	transporter	-
IHN55_RS17935	3696423..3697427	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
IHN55_RS17940	3697424..3698407	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
IHN55_RS17945	3698418..3699320	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T173707 WP_000141634.1 NZ_CP062240:c3694646-3694539 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T173707 NZ_CP080274:3438166-3438744 [Mycolicibacterium smegmatis]
GTGAAACGACTCGATCTCGTCGTTGGTCCCAACGGCGCGGGCAAGAGCACTTTCGTCGAACTCACATTGGCCCCGCTGCT
GACGGGCAGTGCGTTCGTCAACGCCGACGAGATCGCCAAGCGTCGCTGGCCGCACGCCCCGGCCGAGCACTCCTACGAGG
CCGCACGCATCGCCTCCGACACCCGACTCAAGCTGATCGAACTCGGTGAATCGTTCATCGCCGAAACGGTGTTCTCACAT
CCCTCGAAACTTCAGCTCATCGACACCGCGCAGGCGGCTGGATACACCGTGGTAATGCACGTGGTGATGATCCCCGAGGA
TCTCGCCGTCCTACGCGTGCAGCACCGGGTACGAGCCGGTGGTCACCATGTGCCCGAGGAGAAGATCCGCGAACGGCACC
AACGACTCTGGCCCCTCGTCGCGCTGGCGGCCGCCCGCGCCGACATCTCGACGTTCTATGACAACAGCGCCGTCAGGGGT
CCGCGCATCGTTGCCCAACTCGCCGGCGGATTTGCTGTGGGCCGGCCCGCCTGGCCAATGTGGGCACCCCAGGTGCTCAC
CTCGCGGTGGCCCGAATAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT173707 NZ_CP062240:3694695-3694761 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin