Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4948450..4949061 Replicon chromosome
Accession NZ_CP062231
Organism Rhizobium sp. TH2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag IHQ71_RS24180 Protein ID WP_258158958.1
Coordinates 4948777..4949061 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHQ71_RS24175 Protein ID WP_258158957.1
Coordinates 4948450..4948767 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHQ71_RS24155 (IHQ71_24070) 4944218..4945489 + 1272 WP_258158953.1 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB -
IHQ71_RS24160 (IHQ71_24075) 4945626..4947140 + 1515 WP_258158954.1 signal recognition particle-docking protein FtsY -
IHQ71_RS24165 (IHQ71_24080) 4947201..4947863 + 663 WP_258158955.1 septation protein A -
IHQ71_RS24170 (IHQ71_24085) 4947860..4948453 + 594 WP_258158956.1 DUF2585 domain-containing protein -
IHQ71_RS24175 (IHQ71_24090) 4948450..4948767 - 318 WP_258158957.1 HigA family addiction module antitoxin Antitoxin
IHQ71_RS24180 (IHQ71_24095) 4948777..4949061 - 285 WP_258158958.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHQ71_RS24185 (IHQ71_24100) 4949135..4949737 - 603 WP_258158959.1 DsbE family thiol:disulfide interchange protein -
IHQ71_RS24190 (IHQ71_24105) 4949734..4949904 - 171 WP_258162937.1 heme exporter protein CcmD -
IHQ71_RS24195 (IHQ71_24110) 4949910..4950671 - 762 WP_258158960.1 heme ABC transporter permease -
IHQ71_RS24200 (IHQ71_24115) 4950742..4951401 - 660 WP_258158961.1 heme exporter protein CcmB -
IHQ71_RS24205 (IHQ71_24120) 4951426..4951848 - 423 WP_258158962.1 hypothetical protein -
IHQ71_RS24210 (IHQ71_24125) 4951845..4952480 - 636 WP_258162938.1 heme ABC exporter ATP-binding protein CcmA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4942827..4951848 9021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-102)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10599.09 Da        Isoelectric Point: 10.1526

>T173628 WP_258158958.1 NZ_CP062231:c4949061-4948777 [Rhizobium sp. TH2]
MIRSYRSSVTEAVARGRASKGFPADIMKSAQRKLTMLNLAARIEDLLSPPGNRLEALKGNRKGQHSIRINDQWRICFIWS
DGGADQVEIVDYHD

Download         Length: 285 bp

>T173628 NZ_CP080253:2682763-2682870 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCAATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11901.02 Da        Isoelectric Point: 6.7273

>AT173628 WP_258158957.1 NZ_CP062231:c4948767-4948450 [Rhizobium sp. TH2]
MTMKLGDMLPPIHPGEILREEYLIPLEMTPYALAKKLHVPRTRVERIVAEKIGVSADTALRLGKFFKTTPEFWLNMQHSY
DLKIATAAIKDQLASIPEIEQLEAA

Download         Length: 318 bp

>AT173628 NZ_CP080253:c2682716-2682650 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References