Detailed information of TA system TA173626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 3587780..3588361
• Replicon: chromosome
• Accession: NZ_CP062231
• Organism: Rhizobium sp. TH2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IHQ71_RS17680
• Protein ID: WP_258157758.1
• Coordinates: 3587780..3588064 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IHQ71_RS17685
• Protein ID: WP_258157759.1
• Coordinates: 3588074..3588361 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHQ71_RS17650 (IHQ71_17600)	3583326..3583691	+	366	WP_258157753.1	nuclear transport factor 2 family protein	-
IHQ71_RS17655 (IHQ71_17605)	3583732..3583893	-	162	WP_258157754.1	hypothetical protein	-
IHQ71_RS17660 (IHQ71_17610)	3584054..3584947	-	894	WP_258157755.1	branched-chain amino acid aminotransferase	-
IHQ71_RS17665 (IHQ71_17615)	3585219..3585656	+	438	WP_258162872.1	MarR family transcriptional regulator	-
IHQ71_RS17670 (IHQ71_17620)	3585653..3586363	+	711	WP_258157756.1	response regulator transcription factor	-
IHQ71_RS17675 (IHQ71_17625)	3586360..3587742	+	1383	WP_258157757.1	ATP-binding protein	-
IHQ71_RS17680 (IHQ71_17630)	3587780..3588064	+	285	WP_258157758.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IHQ71_RS17685 (IHQ71_17635)	3588074..3588361	+	288	WP_258157759.1	HigA family addiction module antitoxin	Antitoxin
IHQ71_RS17690 (IHQ71_17640)	3588363..3588935	-	573	WP_258157760.1	protein-tyrosine phosphatase family protein	-
IHQ71_RS17695 (IHQ71_17645)	3589000..3589341	-	342	WP_258157761.1	tRNA-binding protein	-
IHQ71_RS17700 (IHQ71_17650)	3589346..3590164	-	819	WP_258157762.1	pyrroline-5-carboxylate reductase	-
IHQ71_RS17705 (IHQ71_17655)	3590161..3590661	-	501	WP_258157763.1	YbjN domain-containing protein	-
IHQ71_RS17710 (IHQ71_17660)	3591027..3591287	-	261	WP_258157764.1	accessory factor UbiK family protein	-
IHQ71_RS17715 (IHQ71_17665)	3591460..3592308	+	849	WP_258157765.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-67)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11129.52 Da
• Isoelectric Point: 6.9799

>T173626 WP_258157758.1 NZ_CP062231:3587780-3588064 [Rhizobium sp. TH2]
MIQSYRDKRTETFANGAFVREFQGFAKQAYKRLDILDAATRLDELRQLPSNQLEALRGNRSGQFSIRINEQYRICFVWRN
DMPGPEEVEIVDYH

Nucleotide

• Length: 285 bp

>T173626 NZ_CP080253:c2471369-2471193 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10515.95 Da
• Isoelectric Point: 8.7932

>AT173626 WP_258157759.1 NZ_CP062231:3588074-3588361 [Rhizobium sp. TH2]
MNQRPAIHPGEILSDELSEIGVAAAELARQIDVPPNRISQIINGKRSITGDTALRLGHWFGTTAQFWLNLQTNYELRLAA
ERSGDAIARLPRRVA

Nucleotide

• Length: 288 bp

>AT173626 NZ_CP080253:c2471147-2470731 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA