Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE(toxin)
Location 1237492..1238100 Replicon chromosome
Accession NZ_CP062231
Organism Rhizobium sp. TH2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IHQ71_RS06285 Protein ID WP_258162759.1
Coordinates 1237492..1237797 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHQ71_RS06290 Protein ID WP_258161095.1
Coordinates 1237807..1238100 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHQ71_RS06265 (IHQ71_06250) 1233740..1234417 + 678 WP_258161092.1 NYN domain-containing protein -
IHQ71_RS06270 (IHQ71_06255) 1234433..1234621 - 189 WP_258161093.1 hypothetical protein -
IHQ71_RS06275 (IHQ71_06260) 1234874..1235878 - 1005 WP_258161094.1 cytochrome d ubiquinol oxidase subunit II -
IHQ71_RS06280 (IHQ71_06265) 1235868..1237277 - 1410 WP_258162758.1 cytochrome ubiquinol oxidase subunit I -
IHQ71_RS06285 (IHQ71_06270) 1237492..1237797 + 306 WP_258162759.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHQ71_RS06290 (IHQ71_06275) 1237807..1238100 + 294 WP_258161095.1 helix-turn-helix domain-containing protein Antitoxin
IHQ71_RS06295 (IHQ71_06280) 1238153..1238557 - 405 WP_258161096.1 hypothetical protein -
IHQ71_RS06300 (IHQ71_06285) 1239080..1240675 + 1596 WP_258161097.1 ABC transporter substrate-binding protein -
IHQ71_RS06305 (IHQ71_06290) 1240762..1241766 + 1005 WP_258161098.1 ABC transporter permease subunit -
IHQ71_RS06310 (IHQ71_06295) 1241776..1242666 + 891 WP_258161099.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(38-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-80)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11447.28 Da        Isoelectric Point: 10.2625

>T173622 WP_258162759.1 NZ_CP062231:1237492-1237797 [Rhizobium sp. TH2]
MPLFIKQAEAVWSIEERSEFIDFIAGNPEAGDLIPGTGGIRKIRWSRGGSGKRGGVRVIYFFYDEVRPLYLLMVYSKARK
ENLTPDETKILRNIAAAISRK

Download         Length: 306 bp

>T173622 NZ_CP080253:1835277-1835531 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11014.67 Da        Isoelectric Point: 9.9881

>AT173622 WP_258161095.1 NZ_CP062231:1237807-1238100 [Rhizobium sp. TH2]
MGRFADELIESMTQALDHARGNKVDGMRLTEVHVPDVRIIRESLHMSQSEFASSFRIPLATIKNWEQGRRRPDAPALAYL
RVIERSPKTVIEAVATK

Download         Length: 294 bp

>AT173622 NZ_CP080253:1835029-1835280 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References