173581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3730431..3731026 Replicon chromosome
Accession NZ_CP062219
Organism Pseudomonas aeruginosa strain JT86

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag IGW72_RS17185 Protein ID WP_003117425.1
Coordinates 3730748..3731026 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IGW72_RS17180 Protein ID WP_003099268.1
Coordinates 3730431..3730736 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGW72_RS17150 3725525..3725833 + 309 WP_058128192.1 DUF4031 domain-containing protein -
IGW72_RS17155 3725891..3726877 + 987 WP_192450193.1 thymidylate synthase -
IGW72_RS17160 3726878..3727675 + 798 WP_096221049.1 hypothetical protein -
IGW72_RS17165 3727675..3728610 + 936 WP_071543738.1 hypothetical protein -
IGW72_RS17170 3728611..3729699 - 1089 WP_071543740.1 ImmA/IrrE family metallo-endopeptidase -
IGW72_RS17175 3729692..3730021 - 330 WP_124142480.1 hypothetical protein -
IGW72_RS17180 3730431..3730736 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
IGW72_RS17185 3730748..3731026 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IGW72_RS17190 3731355..3733583 + 2229 WP_003113525.1 TonB-dependent receptor -
IGW72_RS17195 3733653..3734300 - 648 WP_003095021.1 carbonate dehydratase -
IGW72_RS17200 3734362..3735600 - 1239 WP_033988712.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T173581 WP_003117425.1 NZ_CP062219:c3731026-3730748 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T173581 NZ_CP080247:2657195-2657302 [Escherichia sp. TM-G17TGC]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT173581 WP_003099268.1 NZ_CP062219:c3730736-3730431 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT173581 NZ_CP080247:c2657148-2657082 [Escherichia sp. TM-G17TGC]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References