Detailed information of TA system TA173567

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 43076..43340
• Replicon: plasmid unnamed2
• Accession: NZ_CP062213
• Organism: Escherichia coli strain L3Cip3

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: IFO96_RS25135
• Protein ID: WP_001387489.1
• Coordinates: 43188..43340 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	43076..43136 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFO96_RS25120	39178..40248	-	1071	WP_012783932.1	IncI1-type conjugal transfer protein TrbB	-
IFO96_RS25125	40267..41475	-	1209	WP_001703845.1	IncI1-type conjugal transfer protein TrbA	-
-	41655..41712	-	58	NuclAT_1	-	-
-	41655..41712	-	58	NuclAT_1	-	-
-	41655..41712	-	58	NuclAT_1	-	-
-	41655..41712	-	58	NuclAT_1	-	-
IFO96_RS25130	41782..42873	-	1092	WP_000426061.1	hypothetical protein	-
-	43076..43136	-	61	NuclAT_0	-	Antitoxin
-	43076..43136	-	61	NuclAT_0	-	Antitoxin
-	43076..43136	-	61	NuclAT_0	-	Antitoxin
-	43076..43136	-	61	NuclAT_0	-	Antitoxin
IFO96_RS25135	43188..43340	+	153	WP_001387489.1	Hok/Gef family protein	Toxin
IFO96_RS25140	43412..43663	-	252	WP_001291964.1	hypothetical protein	-
IFO96_RS25145	43963..44259	+	297	WP_011264046.1	hypothetical protein	-
IFO96_RS25150	44324..44500	-	177	WP_001054900.1	hypothetical protein	-
IFO96_RS25155	44892..45101	+	210	WP_000062603.1	HEAT repeat domain-containing protein	-
IFO96_RS25160	45173..45835	-	663	WP_012783935.1	plasmid IncI1-type surface exclusion protein ExcA	-
IFO96_RS25165	45906..48074	-	2169	WP_015508354.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-55	-	1..88924	88924

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T173567 WP_001387489.1 NZ_CP062213:43188-43340 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T173567 NZ_CP080247:c606395-605931 [Escherichia sp. TM-G17TGC]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT173567 NZ_CP062213:c43136-43076 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin