Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 884551..885092 Replicon chromosome
Accession NZ_CP062211
Organism Escherichia coli strain L3Cip3

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag IFO96_RS04270 Protein ID WP_000615982.1
Coordinates 884551..884829 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag IFO96_RS04275 Protein ID WP_000729704.1
Coordinates 884832..885092 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFO96_RS04255 882133..882711 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
IFO96_RS04260 882917..883684 + 768 WP_000333380.1 class II glutamine amidotransferase -
IFO96_RS04265 883655..884395 - 741 WP_001225679.1 murein L,D-transpeptidase -
IFO96_RS04270 884551..884829 - 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IFO96_RS04275 884832..885092 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IFO96_RS04280 885278..885523 + 246 Protein_828 peptidoglycan endopeptidase -
IFO96_RS04285 885501..885893 + 393 WP_032260988.1 flagellar export chaperone FliS -
IFO96_RS04290 885898..886209 + 312 WP_000414996.1 hypothetical protein -
IFO96_RS04295 886206..887267 + 1062 WP_001067469.1 flagellar hook-length control protein FliK -
IFO96_RS04300 887275..887742 + 468 WP_000725257.1 flagellar basal body-associated FliL family protein -
IFO96_RS04305 887762..888478 + 717 WP_000938723.1 FliA/WhiG family RNA polymerase sigma factor -
IFO96_RS04310 888491..888907 + 417 Protein_834 flagellar motor stator protein MotA -
IFO96_RS04315 888972..889676 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn formA - 888972..893207 4235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T173532 WP_000615982.1 NZ_CP062211:c884829-884551 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T173532 NZ_CP080236:21534-21812 [Escherichia coli O139:H1]
ATGGAGATATTCTGGACCATGCTGGCAAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAATGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTGTAT
ATTCTGCGAGTGTTGCATACAGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT173532 WP_000729704.1 NZ_CP062211:c885092-884832 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT173532 NZ_CP080236:21265-21534 [Escherichia coli O139:H1]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCGGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCTCATGACATGGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References