Detailed information of TA system TA173475

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1576034..1576550
• Replicon: chromosome
• Accession: NZ_CP062196
• Organism: Plesiomonas shigelloides strain P5462

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: R8AQQ6
• Locus tag: IHE26_RS06850
• Protein ID: WP_010863491.1
• Coordinates: 1576281..1576550 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: R8AQQ5
• Locus tag: IHE26_RS06845
• Protein ID: WP_010863490.1
• Coordinates: 1576034..1576288 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHE26_RS06825	1571296..1571592	-	297	WP_192437666.1	YkgJ family cysteine cluster protein	-
IHE26_RS06830	1572095..1572556	-	462	WP_192437923.1	lecithin retinol acyltransferase family protein	-
IHE26_RS06835	1573275..1573622	+	348	WP_192437668.1	cupin domain-containing protein	-
IHE26_RS06840	1575071..1575826	+	756	WP_192437670.1	abortive infection family protein	-
IHE26_RS06845	1576034..1576288	+	255	WP_010863490.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IHE26_RS06850	1576281..1576550	+	270	WP_010863491.1	Txe/YoeB family addiction module toxin	Toxin
IHE26_RS06855	1576813..1577277	-	465	WP_192437672.1	ASCH domain-containing protein	-
IHE26_RS06860	1577691..1578335	-	645	WP_192437674.1	hypothetical protein	-
IHE26_RS06865	1579348..1580046	-	699	WP_039044680.1	hypothetical protein	-
IHE26_RS06870	1580578..1581042	-	465	WP_192437676.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	qnrVC4	-	1541277..1622172	80895
	-	inside	Integron	-	-	1553059..1584242	31183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10689.14 Da
• Isoelectric Point: 6.9482

>T173475 WP_010863491.1 NZ_CP062196:1576281-1576550 [Plesiomonas shigelloides]
MSERLLCWTDESWDDYIYWQSQDKKTLKRINKLIIDVKRTPFEGIGKPEALRENLSGFWSRRIDDTNRLVYAVDDLSITI
ISCRYHYQA

Nucleotide

• Length: 270 bp

>T173475 NZ_CP080223:c3852354-3851956 [Escherichia coli O141:H4]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9510.70 Da
• Isoelectric Point: 5.6706

>AT173475 WP_010863490.1 NZ_CP062196:1576034-1576288 [Plesiomonas shigelloides]
MRIVSFTEARNSLKSVLDSVVNDADTTIITRRDADDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGRVTQRE
LKDE

Nucleotide

• Length: 255 bp

>AT173475 NZ_CP080223:c3852650-3852357 [Escherichia coli O141:H4]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: R8AQQ6

Antitoxin

• AlphaFold DB: R8AQQ5