Detailed information of TA system TA173469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5099217..5099806
• Replicon: chromosome
• Accession: NZ_CP062164
• Organism: Xanthomonas arboricola pv. corylina strain A7

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2N7V9W3
• Locus tag: ICA18_RS21840
• Protein ID: WP_016902142.1
• Coordinates: 5099525..5099806 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: ICA18_RS21835
• Protein ID: WP_026064232.1
• Coordinates: 5099217..5099507 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICA18_RS21815 (ICA18_21805)	5094771..5095622	+	852	WP_146091500.1	hypothetical protein	-
ICA18_RS21825 (ICA18_21815)	5097648..5098172	-	525	WP_039816184.1	hypothetical protein	-
ICA18_RS21830 (ICA18_21820)	5098342..5098674	+	333	WP_026064233.1	hypothetical protein	-
ICA18_RS22375	5098824..5099026	+	203	Protein_4289	hypothetical protein	-
ICA18_RS21835 (ICA18_21825)	5099217..5099507	-	291	WP_026064232.1	HigA family addiction module antitoxin	Antitoxin
ICA18_RS21840 (ICA18_21830)	5099525..5099806	-	282	WP_016902142.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICA18_RS21845 (ICA18_21835)	5099946..5102072	-	2127	WP_039816188.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11064.75 Da
• Isoelectric Point: 9.7972

>T173469 WP_016902142.1 NZ_CP062164:c5099806-5099525 [Xanthomonas arboricola pv. corylina]
MIRSFVDKEAEKIWMGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T173469 NZ_CP080223:2379659-2379946 [Escherichia coli O141:H4]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10555.21 Da
• Isoelectric Point: 8.7586

>AT173469 WP_026064232.1 NZ_CP062164:c5099507-5099217 [Xanthomonas arboricola pv. corylina]
MTVLPNIHPGEILREEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLSLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT173469 NZ_CP080223:2379420-2379659 [Escherichia coli O141:H4]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A2N7V9W3