Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1845539..1846239 Replicon chromosome
Accession NZ_CP062122
Organism Pseudomonas sp. ADPe

Toxin (Protein)


Gene name mqsR Uniprot ID A0A1A5CZ88
Locus tag IG194_RS08360 Protein ID WP_058487416.1
Coordinates 1845943..1846239 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A1A5CZ22
Locus tag IG194_RS08355 Protein ID WP_058487415.1
Coordinates 1845539..1845940 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG194_RS08335 1840614..1841282 + 669 WP_173427889.1 ABC transporter permease subunit -
IG194_RS08340 1841279..1842013 + 735 WP_058070655.1 amino acid ABC transporter ATP-binding protein -
IG194_RS08345 1842134..1844020 + 1887 WP_058487413.1 sensor histidine kinase -
IG194_RS08350 1844017..1845345 + 1329 WP_058487414.1 sigma-54 dependent transcriptional regulator -
IG194_RS08355 1845539..1845940 - 402 WP_058487415.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
IG194_RS08360 1845943..1846239 - 297 WP_058487416.1 type II toxin-antitoxin system MqsR family toxin Toxin
IG194_RS08365 1846366..1846818 + 453 WP_058487417.1 hypothetical protein -
IG194_RS08370 1846930..1847160 + 231 WP_009615992.1 hypothetical protein -
IG194_RS08375 1847320..1847559 + 240 WP_009615991.1 hypothetical protein -
IG194_RS08380 1847567..1848178 - 612 WP_058487418.1 class I SAM-dependent methyltransferase -
IG194_RS08385 1848374..1849096 + 723 WP_009615989.1 GntR family transcriptional regulator -
IG194_RS08390 1849093..1849977 + 885 WP_009615988.1 methylisocitrate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(6-97)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10810.56 Da        Isoelectric Point: 9.6266

>T173383 WP_058487416.1 NZ_CP062122:c1846239-1845943 [Pseudomonas sp. ADPe]
MEKSAPHCRLDRVKSLLAQGRVRATYSALSGGAALGLDFAGMLAVIEALAPRDFHKSMTTHADHRVWQDVYRPSTAVGRI
YLKLTVIDDVLVVSFKEL

Download         Length: 297 bp

>T173383 NZ_CP080155:c4722689-4722516 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14472.73 Da        Isoelectric Point: 7.0845

>AT173383 WP_058487415.1 NZ_CP062122:c1845940-1845539 [Pseudomonas sp. ADPe]
MKCPLCGGAELLHETRDLPYAYKGESTLITAVRGEFCPACGEAVLDAEESARVNAQMLAFNKRVNASMVDPGFIAAVRKK
LALDQREAAEIFGGGVNAFSRYENGKTRPPLALVKLLKVLDRHPELLEEVRAG

Download         Length: 402 bp

>AT173383 NZ_CP080155:c4723013-4722717 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5CZ88

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5CZ22

References