Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 251863..252418 Replicon chromosome
Accession NZ_CP062062
Organism Janthinobacterium sp. HH102

Toxin (Protein)


Gene name yoeB Uniprot ID A0A853SUS2
Locus tag JAB4_RS01080 Protein ID WP_070223221.1
Coordinates 251863..252168 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2G3MIP6
Locus tag JAB4_RS01085 Protein ID WP_070223351.1
Coordinates 252149..252418 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JAB4_RS01055 247541..247879 + 339 WP_070223211.1 hypothetical protein -
JAB4_RS01060 247972..250128 + 2157 WP_070223213.1 TonB-dependent receptor -
JAB4_RS01065 250230..250712 - 483 WP_175444800.1 GNAT family N-acetyltransferase -
JAB4_RS01070 250687..250998 - 312 WP_071650246.1 DUF1778 domain-containing protein -
JAB4_RS01075 251104..251772 - 669 WP_070223219.1 uracil-DNA glycosylase -
JAB4_RS01080 251863..252168 - 306 WP_070223221.1 Txe/YoeB family addiction module toxin Toxin
JAB4_RS01085 252149..252418 - 270 WP_070223351.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JAB4_RS01090 252542..253549 - 1008 WP_070223223.1 lipoyl synthase -
JAB4_RS01095 253587..254291 - 705 WP_070223225.1 lipoyl(octanoyl) transferase LipB -
JAB4_RS01100 254367..255851 - 1485 WP_070223227.1 PLP-dependent aminotransferase family protein -
JAB4_RS01105 255977..257248 + 1272 WP_070223229.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(19-98)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11869.50 Da        Isoelectric Point: 7.7710

>T173365 WP_070223221.1 NZ_CP062062:c252168-251863 [Janthinobacterium sp. HH102]
MKNRKTENKQQARAAVLAWTDHAWEDYLFWQENDLKILQKINDLLDACLADPFKGTGKPEPLKGDLTGFWSRRIDRQHRL
VYLPDAGCIYVAACRYHYDDK

Download         Length: 306 bp

>T173365 NZ_CP080155:792734-793144 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACAGGCCTGATGACACGTAA
TAACTACAGAATGGTAAATAACATTACCCTGGGTAGCATCCGGGGGCGAAACGATGAAACTTTCCCTGACGCTGGAAGCC
GACAGCATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9741.12 Da        Isoelectric Point: 6.7153

>AT173365 WP_070223351.1 NZ_CP062062:c252418-252149 [Janthinobacterium sp. HH102]
MNILTFSEARAGLKSVMDDVCNDHTPTVITRVNGEHVVMLSLSDYNSIEETLYLLGTAKNASRLMASVAQIKAGKAQPRA
LARHEKPED

Download         Length: 270 bp

>AT173365 NZ_CP080155:792275-792643 [Escherichia coli]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853SUS2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G3MIP6

References