Detailed information of TA system TA173130

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrE/-
• Location: 2083734..2083996
• Replicon: chromosome
• Accession: NZ_CP061870
• Organism: Bacillus subtilis strain FX-1

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: IE382_RS10890
• Protein ID: WP_009967548.1
• Coordinates: 2083880..2083996 (-)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrE
Locus tag	-
Coordinates	2083734..2083885 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IE382_RS10860 (2078906)	2078906..2079439	+	534	WP_041336408.1	SMI1/KNR4 family protein	-
IE382_RS10865 (2079572)	2079572..2081374	+	1803	WP_041336409.1	LXG family T7SS effector ribonuclease toxin YobL	-
IE382_RS10870 (2081384)	2081384..2081842	+	459	WP_041336410.1	type VII secretion system immunity protein YobK	-
IE382_RS10875 (2081932)	2081932..2082390	+	459	WP_014479998.1	YrhA family protein	-
IE382_RS10880 (2082446)	2082446..2083000	+	555	WP_041336412.1	SMI1/KNR4 family protein	-
IE382_RS10885 (2083060)	2083060..2083593	+	534	WP_014479996.1	GNAT family protein	-
- (2083734)	2083734..2083885	+	152	NuclAT_0	-	Antitoxin
- (2083734)	2083734..2083885	+	152	NuclAT_0	-	Antitoxin
- (2083734)	2083734..2083885	+	152	NuclAT_0	-	Antitoxin
- (2083734)	2083734..2083885	+	152	NuclAT_0	-	Antitoxin
IE382_RS10890 (2083880)	2083880..2083996	-	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
IE382_RS10895 (2084228)	2084228..2084695	+	468	WP_041336414.1	YolA family protein	-
IE382_RS10900 (2084701)	2084701..2085057	+	357	WP_041336416.1	hypothetical protein	-
IE382_RS10905 (2085100)	2085100..2085435	-	336	WP_041336417.1	hypothetical protein	-
IE382_RS10910 (2085608)	2085608..2085940	+	333	WP_041336419.1	YolD-like family protein	-
IE382_RS10915 (2085933)	2085933..2087183	+	1251	WP_064627413.1	UV damage repair protein UvrX	-
IE382_RS10920 (2087285)	2087285..2087602	+	318	WP_009967545.1	sublancin immunity protein SunI	-
IE382_RS10925 (2087899)	2087899..2088069	+	171	WP_009967544.1	bacteriocin sublancin-168	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2067902..2217296	149394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T173130 WP_009967548.1 NZ_CP061870:c2083996-2083880 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T173130 NZ_CP080116:c2391576-2391199 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Nucleotide

• Length: 152 bp

>AT173130 NZ_CP061870:2083734-2083885 [Bacillus subtilis]
TTTCTTTAATGAGAAATGCATAAAATAAAAAGACCAGGGTGTTGGCGCACCCCGGCTCTGTACAAAAAGCTGCCCGTCAA
AGGGCTTGCTCGATGTTCAATCTGCGTAGACCTAACCCTTTAAGGTTCCTAAGCTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin