Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5154262..5154857 Replicon chromosome
Accession NZ_CP061850
Organism Pseudomonas aeruginosa strain R31

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag IE752_RS23975 Protein ID WP_003113526.1
Coordinates 5154579..5154857 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IE752_RS23970 Protein ID WP_003099268.1
Coordinates 5154262..5154567 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE752_RS23940 5149308..5149742 - 435 WP_009875803.1 hypothetical protein -
IE752_RS23945 5150258..5150548 - 291 WP_152959653.1 DUF5447 family protein -
IE752_RS23950 5150724..5150996 - 273 WP_058175553.1 hypothetical protein -
IE752_RS23955 5151443..5151778 + 336 WP_058175552.1 hypothetical protein -
IE752_RS23960 5151781..5152482 - 702 WP_152959654.1 retron Ec48 family effector membrane protein -
IE752_RS23965 5152469..5153644 - 1176 WP_071557852.1 reverse transcriptase family protein -
IE752_RS23970 5154262..5154567 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
IE752_RS23975 5154579..5154857 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE752_RS23980 5155186..5157414 + 2229 WP_003099265.1 TonB-dependent receptor -
IE752_RS23985 5157484..5158131 - 648 WP_003095021.1 carbonate dehydratase -
IE752_RS23990 5158193..5159431 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T173120 WP_003113526.1 NZ_CP061850:c5154857-5154579 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T173120 NZ_CP080116:81787-81894 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT173120 WP_003099268.1 NZ_CP061850:c5154567-5154262 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT173120 NZ_CP080116:c81730-81675 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References