Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 638015..638585 Replicon chromosome
Accession NZ_CP061846
Organism Chryseoglobus sp. 28M-23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IE160_RS03140 Protein ID WP_191151623.1
Coordinates 638015..638296 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IE160_RS03145 Protein ID WP_191151624.1
Coordinates 638283..638585 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE160_RS03125 634649..636304 - 1656 WP_191151620.1 cell wall-binding repeat-containing protein -
IE160_RS03130 636395..637468 + 1074 WP_191151621.1 redox-regulated ATPase YchF -
IE160_RS03135 637478..637771 + 294 WP_191151622.1 hypothetical protein -
IE160_RS03140 638015..638296 + 282 WP_191151623.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE160_RS03145 638283..638585 + 303 WP_191151624.1 HigA family addiction module antidote protein Antitoxin
IE160_RS03150 638655..639050 + 396 WP_191151625.1 VOC family protein -
IE160_RS03155 639190..639345 + 156 WP_191151626.1 hypothetical protein -
IE160_RS03160 639467..639661 + 195 WP_191151955.1 DUF4190 domain-containing protein -
IE160_RS03165 639690..640145 - 456 WP_191151627.1 hypothetical protein -
IE160_RS03170 640368..641315 + 948 WP_179873295.1 virulence RhuM family protein -
IE160_RS03175 641333..641908 - 576 WP_191151628.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
IE160_RS03180 642129..642554 + 426 WP_191151629.1 DUF1761 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 621402..641315 19913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10782.26 Da        Isoelectric Point: 9.2001

>T173101 WP_191151623.1 NZ_CP061846:638015-638296 [Chryseoglobus sp. 28M-23]
VIRSFGNKDTERLWRRERVPSIDPRIHSVALRKLRQVGAATVLDDLRIPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T173101 NZ_CP080099:c4055046-4054657 [Klebsiella quasipneumoniae]
ATGCAAACCAAATCATCCCCCCTCATGCGGGCGGCATCGTCACGTCCGTCTCCGGTGAGTGTCTGGCAGACCCTGCTGAC
CAGCCTGCTGGCACAACACTATGGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAACAGGTCATTCAGCAACATATTG
ATGCCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTC
AGCATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCTATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11043.58 Da        Isoelectric Point: 6.2122

>AT173101 WP_191151624.1 NZ_CP061846:638283-638585 [Chryseoglobus sp. 28M-23]
MTTTDNIPPIHPGEVLMEDFIKGFGITQNRLAVAIGVPPRRINEIVHGTRGISADTALRLSKYFGTSAEFWLNLQTHYEL
DRAQDRAADQIAAITPLQVA

Download         Length: 303 bp

>AT173101 NZ_CP080099:c4055429-4055103 [Klebsiella quasipneumoniae]
ATCAGCGAACCCTGGTGGGGGCTCAGGCGAAGTGTCTCCCCGTGTTTTGGGGCCCGTCTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGGGCGAATGTTAGCGGACAGTTCTGTGATGCGGATTTACGCCATCTTGACCAGGCTTTCCCGA
TATTGCTCAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCACGGCTATGTTTATATCGCGATTTATCCCACTCCTGTCGCCAC
GGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References