Detailed information of TA system TA173084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 350384..351030
• Replicon: chromosome
• Accession: NZ_CP061842
• Organism: Klebsiella pneumoniae strain HC139

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A6G4MDN2
• Locus tag: IEY90_RS01620
• Protein ID: WP_064148407.1
• Coordinates: 350384..350710 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IEY90_RS01625
• Protein ID: WP_064148406.1
• Coordinates: 350731..351030 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEY90_RS01610	346310..347743	+	1434	WP_002920564.1	glycogen synthase GlgA	-
IEY90_RS01615	347761..350208	+	2448	WP_002920561.1	glycogen phosphorylase	-
IEY90_RS01620	350384..350710	+	327	WP_064148407.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IEY90_RS01625	350731..351030	+	300	WP_064148406.1	helix-turn-helix transcriptional regulator	Antitoxin
IEY90_RS01630	351093..352601	-	1509	WP_064148405.1	glycerol-3-phosphate dehydrogenase	-
IEY90_RS01635	352806..353135	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
IEY90_RS01640	353186..354016	+	831	WP_004151408.1	rhomboid family intramembrane serine protease GlpG	-
IEY90_RS01645	354066..354824	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-84)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12625.53 Da
• Isoelectric Point: 5.1769

>T173084 WP_064148407.1 NZ_CP061842:350384-350710 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFS

Nucleotide

• Length: 327 bp

>T173084 NZ_CP080094:c19419-19168 [Salmonella enterica]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10809.60 Da
• Isoelectric Point: 10.1465

>AT173084 WP_064148406.1 NZ_CP061842:350731-351030 [Klebsiella pneumoniae]
MATLKELMAKHSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Nucleotide

• Length: 300 bp

>AT173084 NZ_CP080094:c19181-18954 [Salmonella enterica]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Structures

Toxin

• AlphaFold DB: A0A6G4MDN2