Detailed information of TA system TA173078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1524639..1525141
• Replicon: chromosome
• Accession: NZ_CP061839
• Organism: Treponema pedis strain KS1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: S6A4C3
• Locus tag: IFE08_RS07055
• Protein ID: WP_020965624.1
• Coordinates: 1524881..1525141 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IFE08_RS07050
• Protein ID: WP_194077563.1
• Coordinates: 1524639..1524881 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFE08_RS07035	1520730..1522181	+	1452	WP_024467182.1	aminomethyl-transferring glycine dehydrogenase subunit GcvPB	-
IFE08_RS07040	1522393..1522629	+	237	WP_020965621.1	exodeoxyribonuclease VII small subunit	-
IFE08_RS07045	1522644..1524545	+	1902	WP_194077561.1	DNA mismatch repair endonuclease MutL	-
IFE08_RS07050	1524639..1524881	+	243	WP_194077563.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IFE08_RS07055	1524881..1525141	+	261	WP_020965624.1	Txe/YoeB family addiction module toxin	Toxin
IFE08_RS07060	1525132..1525545	-	414	WP_020965625.1	hypothetical protein	-
IFE08_RS07065	1525549..1526934	-	1386	WP_194077564.1	thiosulfate sulfurtransferase	-
IFE08_RS07070	1527051..1527878	-	828	WP_144299225.1	hypothetical protein	-
IFE08_RS07075	1527938..1528405	-	468	WP_020965628.1	SsrA-binding protein SmpB	-
IFE08_RS07080	1528520..1529566	-	1047	WP_194077566.1	acyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10444.24 Da
• Isoelectric Point: 10.4076

>T173078 WP_020965624.1 NZ_CP061839:1524881-1525141 [Treponema pedis]
MWIIKYAKEAVRDSKKIERSNLKQTVINLIEILKINPFQNPPPYEKLLGDLTGKYSRRINIQHRLVYEVFENKNTVRILR
MWTHYE

Nucleotide

• Length: 261 bp

>T173078 NZ_CP080091:c4180329-4179838 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9184.42 Da
• Isoelectric Point: 4.7571

>AT173078 WP_194077563.1 NZ_CP061839:1524639-1524881 [Treponema pedis]
MMVMTTTQARSNLHTLIDKTKNFHEPIIISGKRHNAVLISEEDWNSIQETLYLYSVPGLRESIIEASKEPLENSIEDIGW

Nucleotide

• Length: 243 bp

>AT173078 NZ_CP080091:c4180619-4180326 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: S6A4C3