Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3573736..3574393 Replicon chromosome
Accession NZ_CP061801
Organism Enterobacter mori strain HSW1412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IDM36_RS17015 Protein ID WP_182272380.1
Coordinates 3573736..3574035 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IDM36_RS17020 Protein ID WP_182272381.1
Coordinates 3574046..3574393 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM36_RS17005 3570094..3572280 + 2187 WP_196390410.1 type I secretion system permease/ATPase -
IDM36_RS17010 3572291..3573460 + 1170 WP_182274564.1 HlyD family efflux transporter periplasmic adaptor subunit -
IDM36_RS17015 3573736..3574035 + 300 WP_182272380.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IDM36_RS17020 3574046..3574393 + 348 WP_182272381.1 HigA family addiction module antidote protein Antitoxin
IDM36_RS17025 3574444..3574962 - 519 WP_182918819.1 hypothetical protein -
IDM36_RS17030 3575048..3576229 - 1182 WP_196390411.1 PLP-dependent aminotransferase family protein -
IDM36_RS17035 3576303..3577199 - 897 WP_182918821.1 LysR family transcriptional regulator -
IDM36_RS17040 3577297..3577899 + 603 WP_182272385.1 short chain dehydrogenase -
IDM36_RS17045 3578044..3578343 + 300 WP_182272386.1 metalloregulator ArsR/SmtB family transcription factor -
IDM36_RS17050 3578353..3578874 + 522 WP_182272387.1 rhodanese family protein -
IDM36_RS17055 3578955..3579134 + 180 WP_182272388.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-102)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11560.23 Da        Isoelectric Point: 9.8985

>T173046 WP_182272380.1 NZ_CP061801:3573736-3574035 [Enterobacter mori]
MINHFRDQWLEDFFLYGKSSNVIPSGLEAALARKLDIINAATSHRDLRSPPGNMYETLNPPLKGFSSIRVNRQYRLVFRW
VEGKADDLYLSPHKYTLYK

Download         Length: 300 bp

>T173046 NZ_CP080085:c2130103-2129696 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13036.04 Da        Isoelectric Point: 6.9802

>AT173046 WP_182272381.1 NZ_CP061801:3574046-3574393 [Enterobacter mori]
MALQQALRKPTTPGDVLQYEYLEPLNLKISDLADMLNVHRNTISALVNNNRKLTADMAIRLAKAFDTTIEFWLNLQLNVD
IWEVQTNSRTQEELGRIKCVAEILAKKKSGQPDVA

Download         Length: 348 bp

>AT173046 NZ_CP080085:c2130350-2130084 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References