Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2162415..2163142 Replicon chromosome
Accession NZ_CP061801
Organism Enterobacter mori strain HSW1412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IDM36_RS10355 Protein ID WP_182271320.1
Coordinates 2162831..2163142 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IDM36_RS10350 Protein ID WP_182918482.1
Coordinates 2162415..2162834 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM36_RS10320 2157722..2158711 - 990 WP_182271312.1 2-hydroxyacid dehydrogenase -
IDM36_RS10325 2159159..2159578 + 420 WP_182274505.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
IDM36_RS10330 2159581..2160846 + 1266 WP_182918483.1 Y-family DNA polymerase -
IDM36_RS10335 2160977..2161222 - 246 Protein_2014 DUF2569 domain-containing protein -
IDM36_RS10340 2161233..2161823 - 591 WP_196391247.1 hypothetical protein -
IDM36_RS10345 2161935..2162345 - 411 WP_196391248.1 hypothetical protein -
IDM36_RS10350 2162415..2162834 - 420 WP_182918482.1 helix-turn-helix domain-containing protein Antitoxin
IDM36_RS10355 2162831..2163142 - 312 WP_182271320.1 type II toxin-antitoxin system HigB family toxin Toxin
IDM36_RS10360 2163518..2164330 - 813 WP_196391249.1 LysR family transcriptional regulator -
IDM36_RS10365 2164311..2165342 - 1032 WP_032425611.1 IS630-like element ISEc33 family transposase -
IDM36_RS10370 2165444..2165563 - 120 Protein_2021 LysR family transcriptional regulator -
IDM36_RS10375 2165693..2166298 + 606 WP_196391250.1 glutathione transferase GstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2164311..2165342 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12454.35 Da        Isoelectric Point: 10.2554

>T173036 WP_182271320.1 NZ_CP061801:c2163142-2162831 [Enterobacter mori]
MHVVSRAPFDAATRQFPNQALALHDLYRVLKKEHYPSPDDMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFTDFERGKI
FIKHISTHAEYDKLTDLYRRTKE

Download         Length: 312 bp

>T173036 NZ_CP080082:c35513-35238 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGCGCTGGCCAGTAAACCAGC
TGCAGCCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTATGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15379.39 Da        Isoelectric Point: 4.4698

>AT173036 WP_182918482.1 NZ_CP061801:c2162834-2162415 [Enterobacter mori]
MNYAAVIKAANDLTNALPFLGSSPSRQDYEDALALVEYLVEHEPDSPLVEMLTAKIDQYENESPEFADFNARVASIPSGV
ALLRTLMDQYQLTQSDFETEIGKKSLVSRILNGQRTLTLDHMRALAKRFGVPVSAFVGN

Download         Length: 420 bp

>AT173036 NZ_CP080082:c35797-35513 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGTAACAAAAGTAATTACTGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGGTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCGGTACTGACAATCCGTTACCGGTGCCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References