Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 46234..46880 Replicon chromosome
Accession NZ_CP061801
Organism Enterobacter mori strain HSW1412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IDM36_RS00250 Protein ID WP_196391340.1
Coordinates 46530..46880 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IDM36_RS00245 Protein ID WP_196390657.1
Coordinates 46234..46533 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM36_RS00215 41546..42529 - 984 WP_196390655.1 LysR family transcriptional regulator -
IDM36_RS00220 42645..42959 + 315 WP_182919179.1 DUF1330 domain-containing protein -
IDM36_RS00225 42971..43498 + 528 WP_182273145.1 NAD(P)H-dependent oxidoreductase -
IDM36_RS00230 43556..44515 - 960 WP_182273144.1 DUF523 and DUF1722 domain-containing protein -
IDM36_RS00235 44677..45675 + 999 WP_182273143.1 class I SAM-dependent methyltransferase -
IDM36_RS00240 45779..46216 + 438 WP_196390656.1 GNAT family N-acetyltransferase -
IDM36_RS00245 46234..46533 - 300 WP_196390657.1 XRE family transcriptional regulator Antitoxin
IDM36_RS00250 46530..46880 - 351 WP_196391340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IDM36_RS00255 47274..47615 - 342 WP_196390658.1 SymE family type I addiction module toxin -
IDM36_RS00260 47752..47934 + 183 WP_196390659.1 toxin-antitoxin system HicB family antitoxin -
IDM36_RS00265 47967..49523 - 1557 WP_196390660.1 hypothetical protein -
IDM36_RS00270 49604..50301 + 698 Protein_53 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13516.61 Da        Isoelectric Point: 7.9791

>T173030 WP_196391340.1 NZ_CP061801:c46880-46530 [Enterobacter mori]
MWTVLFGKVFELWLLEQEEGLQEKVLADMLNLQNYGPRLPRPYADTVKGSQYKNMKELRIQYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKTFYEKLIRIADDEFTRHLTSLEAAK

Download         Length: 351 bp

>T173030 NZ_CP080080:3346371-3346589 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11146.01 Da        Isoelectric Point: 6.9842

>AT173030 WP_196390657.1 NZ_CP061801:c46533-46234 [Enterobacter mori]
VKTLNEVIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKNVAELMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp

>AT173030 NZ_CP080080:3345971-3346345 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References