Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 7628890..7629518 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag dnm_RS29220 Protein ID WP_207680385.1
Coordinates 7629198..7629518 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag dnm_RS29215 Protein ID WP_207680384.1
Coordinates 7628890..7629201 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS29215 (dnm_095430) 7628890..7629201 - 312 WP_207680384.1 helix-turn-helix transcriptional regulator Antitoxin
dnm_RS29220 (dnm_095440) 7629198..7629518 - 321 WP_207680385.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
dnm_RS29225 (dnm_095470) 7630102..7630563 + 462 WP_207680386.1 (2Fe-2S)-binding protein -
dnm_RS29230 (dnm_095480) 7630567..7632711 + 2145 WP_207680387.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-90)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12247.37 Da        Isoelectric Point: 10.5606

>T173029 WP_207680385.1 NZ_CP061800:c7629518-7629198 [Desulfonema magnum]
MNWEIYYYNEKVQNEIDSWPVSIRAVYARITERIIVFGPNLGLPLTRSMGDGLFEIRAKGREGIGRAFFCTVIGSKVIIL
HSFIKKSQKTPVNELRIARKRMKEVS

Download         Length: 321 bp

>T173029 NZ_CP080080:2574475-2574582 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11452.30 Da        Isoelectric Point: 9.8783

>AT173029 WP_207680384.1 NZ_CP061800:c7629201-7628890 [Desulfonema magnum]
MKSHNEMVSGWMEDPVFKAEYDALEDKFALFDELIKARKKAGLTQAEVARRMDTKVPAIARLESGGGSKQHSPSVATLNK
YAKAVGCRLEIKLHPLTKIPNQL

Download         Length: 312 bp

>AT173029 NZ_CP080080:c2574428-2574362 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References