Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5471775..5472364 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag dnm_RS20965 Protein ID WP_207678849.1
Coordinates 5471775..5472056 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag dnm_RS20970 Protein ID WP_207678850.1
Coordinates 5472065..5472364 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS20935 (dnm_068760) 5466921..5469416 + 2496 WP_207678843.1 hypothetical protein -
dnm_RS20940 (dnm_068770) 5469391..5470059 + 669 WP_207678844.1 WD40 repeat domain-containing protein -
dnm_RS20945 (dnm_068790) 5470368..5470676 + 309 WP_207678845.1 BrnT family toxin -
dnm_RS20950 (dnm_068800) 5470651..5470923 + 273 WP_207678846.1 hypothetical protein -
dnm_RS20955 (dnm_068810) 5470974..5471270 + 297 WP_207678847.1 HigA family addiction module antitoxin -
dnm_RS20960 (dnm_068830) 5471563..5471778 + 216 WP_207678848.1 hypothetical protein -
dnm_RS20965 (dnm_068840) 5471775..5472056 + 282 WP_207678849.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
dnm_RS20970 (dnm_068850) 5472065..5472364 + 300 WP_207678850.1 HigA family addiction module antitoxin Antitoxin
dnm_RS20975 (dnm_068860) 5472667..5472897 + 231 WP_207678851.1 hypothetical protein -
dnm_RS20980 (dnm_068870) 5472887..5473270 + 384 WP_207678852.1 DUF6516 family protein -
dnm_RS20985 (dnm_068880) 5473926..5474546 - 621 WP_207678853.1 BadF/BadG/BcrA/BcrD ATPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10972.49 Da        Isoelectric Point: 9.5997

>T173027 WP_207678849.1 NZ_CP061800:5471775-5472056 [Desulfonema magnum]
MIKTFKQNWLEAFFHGGKHKRVPSQLKRQLRHKLDMLNSASVLRDLESPPGNHLHPLSREREGEYAISVNGPWRLCFRFE
NGDAYDVELVQYH

Download         Length: 282 bp

>T173027 NZ_CP080080:c2391800-2391624 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11517.06 Da        Isoelectric Point: 5.9657

>AT173027 WP_207678850.1 NZ_CP061800:5472065-5472364 [Desulfonema magnum]
MLPKHRRPTHPGEILKYEYLDLLGMTESQLAEFIGISLNTVNELVSGEHPVSSDIAFRLARFFNTSTEFWLNLQRNVDLW
DTFQAHSHEYEKISPLKTV

Download         Length: 300 bp

>AT173027 NZ_CP080080:c2391578-2391162 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References