Detailed information of TA system TA173025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3123572..3124133
• Replicon: chromosome
• Accession: NZ_CP061800
• Organism: Desulfonema magnum strain 4be13

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: dnm_RS12380
• Protein ID: WP_207683660.1
• Coordinates: 3123572..3123829 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: dnm_RS12385
• Protein ID: WP_207682957.1
• Coordinates: 3123843..3124133 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dnm_RS12365 (dnm_040220)	3122009..3122170	+	162	WP_207682954.1	hypothetical protein	-
dnm_RS12370	3122248..3123168	+	921	WP_207682955.1	hypothetical protein	-
dnm_RS12375	3123153..3123425	+	273	WP_207682956.1	hypothetical protein	-
dnm_RS12380 (dnm_040260)	3123572..3123829	+	258	WP_207683660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
dnm_RS12385 (dnm_040270)	3123843..3124133	+	291	WP_207682957.1	HigA family addiction module antitoxin	Antitoxin
dnm_RS12390 (dnm_040280)	3124563..3125468	-	906	WP_207682958.1	response regulator	-
dnm_RS12395 (dnm_040290)	3125567..3126178	-	612	WP_207682959.1	hypothetical protein	-
dnm_RS12400 (dnm_040300)	3126271..3127200	-	930	WP_207682960.1	inorganic phosphate transporter	-
dnm_RS12405 (dnm_040310)	3127280..3127912	-	633	WP_207682961.1	TIGR00153 family protein	-
dnm_RS12410 (dnm_040320)	3127902..3128306	-	405	WP_207682962.1	CBS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (6-85)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-85)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9766.08 Da
• Isoelectric Point: 8.5567

>T173025 WP_207683660.1 NZ_CP061800:3123572-3123829 [Desulfonema magnum]
ITREPLFETGKNTGIRPEHAQRLRRILALLETASVIEDMDLPGLNLHELKGKRRGTWSVKVSGNWRITFQITGGDVYNVS
YEDYH

Nucleotide

• Length: 258 bp

>T173025 NZ_CP080080:1954240-1954343 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10827.71 Da
• Isoelectric Point: 9.6306

>AT173025 WP_207682957.1 NZ_CP061800:3123843-3124133 [Desulfonema magnum]
MRMYNPPHPGEIIRECCVEALGLKIADAAKALGVSPKKLSALLRGKTGISPEMALRLSKVFGRTPEGWLRLQYQYDLWKT
EQQTDLTALRRIQAEC

Nucleotide

• Length: 291 bp

>AT173025 NZ_CP080080:c1954381-1954110 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT