Detailed information of TA system TA173013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 2818712..2819214
• Replicon: chromosome
• Accession: NZ_CP061799
• Organism: Desulfonema limicola strain 5ac10

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: dnl_RS12040
• Protein ID: WP_275950232.1
• Coordinates: 2818712..2818978 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: dnl_RS12045
• Protein ID: WP_207691972.1
• Coordinates: 2818972..2819214 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dnl_RS12015 (dnl_26030)	2813844..2814095	-	252	WP_207691969.1	hypothetical protein	-
dnl_RS12020 (dnl_26040)	2814186..2815568	-	1383	WP_207689402.1	IS4 family transposase	-
dnl_RS12025 (dnl_26050)	2815718..2816716	-	999	WP_275950248.1	DUF1566 domain-containing protein	-
dnl_RS12030 (dnl_26060)	2816819..2818201	+	1383	WP_207689402.1	IS4 family transposase	-
dnl_RS12035 (dnl_26070)	2818193..2818519	-	327	WP_207691971.1	caspase family protein	-
dnl_RS12040 (dnl_26090)	2818712..2818978	-	267	WP_275950232.1	Txe/YoeB family addiction module toxin	Toxin
dnl_RS12045 (dnl_26100)	2818972..2819214	-	243	WP_207691972.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
dnl_RS12050 (dnl_26110)	2819269..2819700	-	432	WP_207691973.1	hypothetical protein	-
dnl_RS12055 (dnl_26120)	2819812..2821518	-	1707	WP_207691974.1	DUF4384 domain-containing protein	-
dnl_RS12060 (dnl_26130)	2821541..2821936	-	396	WP_207691975.1	hypothetical protein	-
dnl_RS12065 (dnl_26150)	2822003..2822614	-	612	WP_207691976.1	hypothetical protein	-
dnl_RS12070 (dnl_26170)	2823137..2823925	+	789	WP_207691977.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10391.28 Da
• Isoelectric Point: 10.3703

>T173013 WP_275950232.1 NZ_CP061799:c2818978-2818712 [Desulfonema limicola]
MVMWEIVYTKQALKDAKKLSSAGLRPKADNLIKILKENPWQKPPPYEKLIGDLSGAYSRRINIQHRLVYQIIEQVNVVKV
IRMWTHYE

Nucleotide

• Length: 267 bp

>T173013 NZ_CP080075:3707316-3707594 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9060.27 Da
• Isoelectric Point: 4.0202

>AT173013 WP_207691972.1 NZ_CP061799:c2819214-2818972 [Desulfonema limicola]
MLPINASEAQTKLYDLIDETAVSHKPVIITGKNSNAVLISEEDWVSVQETLYLLSIPNMRESIREGLDTPLTECEKEIEW

Nucleotide

• Length: 243 bp

>AT173013 NZ_CP080075:3707053-3707313 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA