Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1404234..1404803 Replicon chromosome
Accession NZ_CP061799
Organism Desulfonema limicola strain 5ac10

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag dnl_RS29925 Protein ID WP_275950242.1
Coordinates 1404234..1404464 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag dnl_RS05890 Protein ID WP_207690828.1
Coordinates 1404474..1404803 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnl_RS05860 (dnl_12730) 1399844..1400827 + 984 WP_207690822.1 signal peptide peptidase SppA -
dnl_RS05865 (dnl_12740) 1400957..1401958 + 1002 WP_207690823.1 hypothetical protein -
dnl_RS05870 (dnl_12760) 1402214..1402927 + 714 WP_207690824.1 TIGR04255 family protein -
dnl_RS05875 (dnl_12770) 1402943..1403254 + 312 WP_207690825.1 hypothetical protein -
dnl_RS05880 (dnl_12780) 1403251..1403865 + 615 WP_207690826.1 hypothetical protein -
dnl_RS29925 (dnl_12790) 1404234..1404464 + 231 WP_275950242.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
dnl_RS05890 (dnl_12800) 1404474..1404803 + 330 WP_207690828.1 HigA family addiction module antitoxin Antitoxin
dnl_RS05895 (dnl_12820) 1405330..1406127 + 798 WP_207690829.1 nucleoside triphosphate pyrophosphohydrolase -
dnl_RS29560 1406117..1406380 - 264 WP_246514873.1 hypothetical protein -
dnl_RS05905 (dnl_12850) 1406726..1408465 + 1740 WP_207690831.1 hypothetical protein -
dnl_RS05910 1408663..1408896 + 234 WP_207690832.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-76)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 9084.44 Da        Isoelectric Point: 10.6224

>T173010 WP_275950242.1 NZ_CP061799:1404234-1404464 [Desulfonema limicola]
MRVRRFQSFERQARKRLMVLNAAPTLESLMLIPGNKFHSLSGNRKGQYSISINKQWRICFEWNDGHVYNVEITDYH

Download         Length: 231 bp

>T173010 NZ_CP080075:c2923731-2923354 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12504.61 Da        Isoelectric Point: 9.5333

>AT173010 WP_207690828.1 NZ_CP061799:1404474-1404803 [Desulfonema limicola]
MDKNEILSPITPGEVLYDDFMKPLGISINQLARDIVVPPNRISAIVNGKRGITADTALRLQRYFSVDAQFWLNLQAEYDL
RIIKRKIWSDIEKRIIPIKRADIDPILAT

Download         Length: 330 bp

>AT173010 NZ_CP080075:c2924189-2923821 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAACATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References