173007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 423231..423853 Replicon chromosome
Accession NZ_CP061799
Organism Desulfonema limicola strain 5ac10

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag dnl_RS01730 Protein ID WP_207690057.1
Coordinates 423231..423512 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag dnl_RS01735 Protein ID WP_207690058.1
Coordinates 423554..423853 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnl_RS29535 (dnl_03720) 418246..418524 - 279 WP_246514850.1 hypothetical protein -
dnl_RS01705 (dnl_03730) 418521..419270 - 750 WP_246514851.1 amino acid ABC transporter substrate-binding protein -
dnl_RS01710 (dnl_03740) 419563..420588 + 1026 WP_207690053.1 3-deoxy-7-phosphoheptulonate synthase -
dnl_RS01715 (dnl_03750) 420632..421333 - 702 WP_207690054.1 RNA pseudouridine synthase -
dnl_RS01720 (dnl_03760) 421505..422179 + 675 WP_207690055.1 DUF1847 domain-containing protein -
dnl_RS01725 (dnl_03770) 422200..423189 + 990 WP_207690056.1 potassium channel protein -
dnl_RS01730 (dnl_03780) 423231..423512 + 282 WP_207690057.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
dnl_RS01735 (dnl_03790) 423554..423853 + 300 WP_207690058.1 HigA family addiction module antitoxin Antitoxin
dnl_RS01740 (dnl_03800) 424088..426052 - 1965 WP_207690059.1 DUF3488 and transglutaminase-like domain-containing protein -
dnl_RS01745 (dnl_03810) 426059..427012 - 954 WP_207690060.1 DUF58 domain-containing protein -
dnl_RS01750 (dnl_03820) 427009..427935 - 927 WP_246514852.1 MoxR family ATPase -
dnl_RS01755 (dnl_03830) 428015..428599 - 585 WP_207690062.1 ATP synthase F0 subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-92)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11316.94 Da        Isoelectric Point: 9.5270

>T173007 WP_207690057.1 NZ_CP061799:423231-423512 [Desulfonema limicola]
MIVSFKNKETEKIFNRRFSKKLPHDIQRKALEKLWMIDVADDLSALRIPPGNRLEALEHDRKGQYSIRINDQWRICFKWN
RNNAYDVEIEDYH

Download         Length: 282 bp

>T173007 NZ_CP080075:2592224-2592331 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11227.88 Da        Isoelectric Point: 4.5431

>AT173007 WP_207690058.1 NZ_CP061799:423554-423853 [Desulfonema limicola]
MNEEKIPPIHPGETLLGEFLEPMGISRARIAKSLSVPESVITDIIQGKKSVTADIALRLGRYFRMSPQFWMGLQNHYDLA
IAEDELENRLEQEVELYAA

Download         Length: 300 bp

>AT173007 NZ_CP080075:c2592176-2592109 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References