Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1538378..1538973 | Replicon | chromosome |
Accession | NZ_CP061780 | ||
Organism | Pseudomonas aeruginosa strain ZBX-P11 |
Toxin (Protein)
Gene name | higB | Uniprot ID | V6ALY3 |
Locus tag | IFJ77_RS07310 | Protein ID | WP_003113526.1 |
Coordinates | 1538695..1538973 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0S3KUN4 |
Locus tag | IFJ77_RS07305 | Protein ID | WP_003111575.1 |
Coordinates | 1538378..1538683 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IFJ77_RS07270 (IFJ77_07270) | 1533530..1534378 | + | 849 | WP_009878189.1 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | - |
IFJ77_RS07280 (IFJ77_07280) | 1534545..1535486 | + | 942 | WP_003099281.1 | ribose-phosphate pyrophosphokinase | - |
IFJ77_RS07285 (IFJ77_07285) | 1535603..1536217 | + | 615 | WP_003095013.1 | 50S ribosomal protein L25/general stress protein Ctc | - |
IFJ77_RS07290 (IFJ77_07290) | 1536258..1536842 | + | 585 | WP_003099278.1 | aminoacyl-tRNA hydrolase | - |
IFJ77_RS07295 (IFJ77_07295) | 1536883..1537983 | + | 1101 | WP_003099270.1 | redox-regulated ATPase YchF | - |
IFJ77_RS07305 (IFJ77_07305) | 1538378..1538683 | - | 306 | WP_003111575.1 | HigA family addiction module antitoxin | Antitoxin |
IFJ77_RS07310 (IFJ77_07310) | 1538695..1538973 | - | 279 | WP_003113526.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
IFJ77_RS31290 | 1539026..1539154 | - | 129 | Protein_1445 | integrase | - |
IFJ77_RS07315 (IFJ77_07315) | 1539302..1541530 | + | 2229 | WP_021264080.1 | TonB-dependent receptor | - |
IFJ77_RS07320 (IFJ77_07320) | 1541600..1542247 | - | 648 | WP_003095021.1 | carbonate dehydratase | - |
IFJ77_RS07325 (IFJ77_07325) | 1542309..1543547 | - | 1239 | WP_003111578.1 | C69 family dipeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10646.19 Da Isoelectric Point: 7.8937
>T173002 WP_003113526.1 NZ_CP061780:c1538973-1538695 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T173002 NZ_CP080075:1780215-1780466 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11205.72 Da Isoelectric Point: 4.4475
>AT173002 WP_003111575.1 NZ_CP061780:c1538683-1538378 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG
Download Length: 306 bp
>AT173002 NZ_CP080075:1780463-1780717 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATATCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATATCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V6ALY3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0S3KUN4 |