Detailed information of TA system TA172833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3206..3791
• Replicon: plasmid p6E072658
• Accession: NZ_CP061708
• Organism: Acinetobacter baumannii strain E-072658

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N8ZPD7
• Locus tag: H2787_RS18270
• Protein ID: WP_000897309.1
• Coordinates: 3471..3791 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H2787_RS18265
• Protein ID: WP_130114462.1
• Coordinates: 3206..3478 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2787_RS18245 (H2787_18240)	1..924	+	924	WP_000845851.1	replication initiation protein RepM	-
H2787_RS18250 (H2787_18245)	992..1537	+	546	WP_000736774.1	plasmid replication DNA-binding protein	-
H2787_RS18255 (H2787_18250)	1723..1959	-	237	WP_016659738.1	hypothetical protein	-
H2787_RS18260 (H2787_18255)	1986..2555	-	570	WP_016659739.1	hypothetical protein	-
H2787_RS18265 (H2787_18260)	3206..3478	-	273	WP_130114462.1	NadS family protein	Antitoxin
H2787_RS18270 (H2787_18265)	3471..3791	-	321	WP_000897309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H2787_RS18275 (H2787_18270)	4019..4672	+	654	WP_005086345.1	hypothetical protein	-
H2787_RS18280 (H2787_18275)	5107..6078	-	972	WP_223106973.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..18806	18806

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12209.01 Da
• Isoelectric Point: 7.9835

>T172833 WP_000897309.1 NZ_CP061708:c3791-3471 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T172833 NZ_CP079991:c784414-784157 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10036.49 Da
• Isoelectric Point: 8.6797

>AT172833 WP_130114462.1 NZ_CP061708:c3478-3206 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTALELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT172833 NZ_CP079991:c784145-783600 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: A0A855WJQ3