Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5177..5828 Replicon plasmid p7E072658
Accession NZ_CP061707
Organism Acinetobacter baumannii strain E-072658

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H2787_RS18155 Protein ID WP_055414415.1
Coordinates 5177..5533 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H2787_RS18160 Protein ID WP_055414414.1
Coordinates 5526..5828 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2787_RS18140 (H2787_18135) 618..1565 + 948 WP_223106967.1 replication initiation protein RepM -
H2787_RS18145 (H2787_18140) 1558..2112 + 555 WP_223106968.1 plasmid replication DNA-binding protein -
H2787_RS18795 2132..2266 + 135 WP_258170872.1 hypothetical protein -
H2787_RS18150 (H2787_18145) 2558..4408 - 1851 WP_223106969.1 choice-of-anchor I family protein -
H2787_RS18155 (H2787_18150) 5177..5533 + 357 WP_055414415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2787_RS18160 (H2787_18155) 5526..5828 + 303 WP_055414414.1 XRE family transcriptional regulator Antitoxin
H2787_RS18765 6017..6148 + 132 Protein_7 DNA starvation/stationary phase protection protein -
H2787_RS18165 (H2787_18160) 6243..7541 - 1299 WP_086209421.1 dicarboxylate/amino acid:cation symporter -
H2787_RS18170 (H2787_18165) 7647..8297 + 651 Protein_9 IS5-like element IS17 family transposase -
H2787_RS18175 (H2787_18170) 8509..8904 + 396 WP_223106970.1 transposase family protein -
H2787_RS18180 (H2787_18175) 8852..9322 + 471 WP_223106971.1 transposase family protein -
H2787_RS18185 (H2787_18180) 9401..9667 - 267 WP_223106972.1 mobilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 - 1..19661 19661
- flank IS/Tn - - 7737..8297 560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13559.50 Da        Isoelectric Point: 5.7286

>T172831 WP_055414415.1 NZ_CP061707:5177-5533 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYNSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGGKKRFYKEMLDIADEQYELHLSTLGDQSNG

Download         Length: 357 bp

>T172831 NZ_CP079991:603269-603442 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11214.02 Da        Isoelectric Point: 6.4759

>AT172831 WP_055414414.1 NZ_CP061707:5526-5828 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT172831 NZ_CP079991:602945-603241 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References