Detailed information of TA system TA172793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1303221..1303816
• Replicon: chromosome
• Accession: NZ_CP061699
• Organism: Pseudomonas aeruginosa strain LYSZa7

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A6N0KDU0
• Locus tag: LYSZa7_RS05990
• Protein ID: WP_023436306.1
• Coordinates: 1303221..1303499 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LYSZa7_RS05995
• Protein ID: WP_003133769.1
• Coordinates: 1303511..1303816 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LYSZa7_RS05975	1298646..1299884	+	1239	WP_014603324.1	C69 family dipeptidase	-
LYSZa7_RS05980	1299946..1300593	+	648	WP_003095021.1	carbonate dehydratase	-
LYSZa7_RS05985	1300664..1302892	-	2229	WP_073647417.1	TonB-dependent receptor	-
LYSZa7_RS05990	1303221..1303499	+	279	WP_023436306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LYSZa7_RS05995	1303511..1303816	+	306	WP_003133769.1	HigA family addiction module antidote protein	Antitoxin
LYSZa7_RS06005	1304222..1305322	-	1101	WP_003099270.1	redox-regulated ATPase YchF	-
LYSZa7_RS06010	1305363..1305947	-	585	WP_003099278.1	aminoacyl-tRNA hydrolase	-
LYSZa7_RS06015	1305989..1306603	-	615	WP_003095013.1	50S ribosomal protein L25/general stress protein Ctc	-
LYSZa7_RS06020	1306720..1307661	-	942	WP_003099281.1	ribose-phosphate pyrophosphokinase	-
LYSZa7_RS06030	1307828..1308676	-	849	WP_009316211.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10588.11 Da
• Isoelectric Point: 7.2451

>T172793 WP_023436306.1 NZ_CP061699:1303221-1303499 [Pseudomonas aeruginosa]
MILTFRCDEARQLFETGLSRQWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Nucleotide

• Length: 279 bp

>T172793 NZ_CP079926:3473973-3474161 [Caulobacter vibrioides]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCAACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGTGACTTGCCGCTAGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11214.73 Da
• Isoelectric Point: 4.6081

>AT172793 WP_003133769.1 NZ_CP061699:1303511-1303816 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Nucleotide

• Length: 306 bp

>AT172793 NZ_CP079926:3474166-3474561 [Caulobacter vibrioides]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCCCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A6N0KDU0