Detailed information of TA system TA172791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 84573..85224
• Replicon: plasmid pAS5-2
• Accession: NZ_CP061685
• Organism: Acinetobacter seifertii strain AS5

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7H2WXC0
• Locus tag: IC764_RS20795
• Protein ID: WP_006581604.1
• Coordinates: 84573..84929 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IC764_RS20800
• Protein ID: WP_001140619.1
• Coordinates: 84922..85224 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC764_RS20775	80030..81238	-	1209	WP_004832869.1	IS256-like element ISAba26 family transposase	-
IC764_RS20780	81523..81699	+	177	WP_006581600.1	hypothetical protein	-
IC764_RS20785	81733..82095	+	363	Protein_86	DNA-binding protein	-
IC764_RS20790	82309..83763	-	1455	WP_062032131.1	SulP family inorganic anion transporter	-
IC764_RS20795	84573..84929	+	357	WP_006581604.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IC764_RS20800	84922..85224	+	303	WP_001140619.1	XRE family transcriptional regulator	Antitoxin
IC764_RS20805	85217..85426	+	210	WP_000069471.1	hypothetical protein	-
IC764_RS20810	85536..85754	-	219	WP_029747731.1	hypothetical protein	-
IC764_RS20820	87664..87977	-	314	Protein_93	AAA family ATPase	-
IC764_RS20825	88163..88483	+	321	WP_002123990.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
IC764_RS20830	88760..88948	+	189	WP_000033474.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IC764_RS20835	88935..89224	+	290	Protein_96	helix-turn-helix domain-containing protein	-
IC764_RS20840	89303..89557	-	255	WP_000236586.1	hypothetical protein	-
IC764_RS20845	89508..89805	-	298	Protein_98	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..105818	105818
	-	flank	IS/Tn	-	-	80030..81238	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13462.38 Da
• Isoelectric Point: 7.1642

>T172791 WP_006581604.1 NZ_CP061685:84573-84929 [Acinetobacter seifertii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T172791 NZ_CP079926:c3028520-3027213 [Caulobacter vibrioides]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCAGTGTCGCTGGAGGACGGCGCGGAGACGGCGGT
CTTCGCCTATGAGCCGAGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCCTCTGAGGTTCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCGAC
CAACGAGGTGCGCTCCGGCCAGGTCGAGGCCGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCCCTGGCCGCCATCGCTCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAGC
AGGCCCTGTTCACCATGCGGCGGATGGGCTTGTCGATGGCGCAGCTGGAGGAGCAGTTCCGGCGCATGGTCTTCAACGTG
CTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCCGGACGCTGGCGCCTGTCGCCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTCGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGTGGTCACGTCGGCCGGATTTTCGATGAG
GTGCGGGAGGCCGTGATGCGGTGGCCGACCTTCGCCGACGCGGCCGGGGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
TACGGTGCGGCTGGAGCTCAGGCGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11206.01 Da
• Isoelectric Point: 6.7282

>AT172791 WP_001140619.1 NZ_CP061685:84922-85224 [Acinetobacter seifertii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT172791 NZ_CP079926:c3028876-3028517 [Caulobacter vibrioides]
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTATCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCCTGGGTGTGGGGCGATGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A7H2WXC0