Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 45493..46144 Replicon plasmid pAS25-1
Accession NZ_CP061667
Organism Acinetobacter seifertii strain AS25

Toxin (Protein)


Gene name higB Uniprot ID A0A7H2WXC0
Locus tag IC771_RS20070 Protein ID WP_006581604.1
Coordinates 45493..45849 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IC771_RS20075 Protein ID WP_001140619.1
Coordinates 45842..46144 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC771_RS20050 40949..42157 - 1209 WP_004832869.1 IS256-like element ISAba26 family transposase -
IC771_RS20055 42442..42618 + 177 WP_006581600.1 hypothetical protein -
IC771_RS20060 42652..43014 + 363 Protein_44 DNA-binding protein -
IC771_RS20065 43228..44682 - 1455 WP_062032131.1 SulP family inorganic anion transporter -
IC771_RS20070 45493..45849 + 357 WP_006581604.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IC771_RS20075 45842..46144 + 303 WP_001140619.1 XRE family transcriptional regulator Antitoxin
IC771_RS20080 46137..46346 + 210 WP_000069471.1 hypothetical protein -
IC771_RS20085 46456..46674 - 219 WP_029747731.1 hypothetical protein -
IC771_RS20095 48584..48897 - 314 Protein_51 AAA family ATPase -
IC771_RS20100 49083..49403 + 321 WP_002123990.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IC771_RS20105 49680..49868 + 189 WP_000033474.1 type II toxin-antitoxin system RelE/ParE family toxin -
IC771_RS20110 49855..50144 + 290 Protein_54 helix-turn-helix domain-containing protein -
IC771_RS20115 50223..50477 - 255 WP_000236586.1 hypothetical protein -
IC771_RS20120 50428..50725 - 298 Protein_56 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..105815 105815
- flank IS/Tn - - 40949..42157 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13462.38 Da        Isoelectric Point: 7.1642

>T172781 WP_006581604.1 NZ_CP061667:45493-45849 [Acinetobacter seifertii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

>T172781 NZ_CP079924:2608911-2609018 [Escherichia sp. TC-EC600-tetX4]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT172781 WP_001140619.1 NZ_CP061667:45842-46144 [Acinetobacter seifertii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT172781 NZ_CP079924:c2608864-2608798 [Escherichia sp. TC-EC600-tetX4]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H2WXC0

Antitoxin

Source ID Structure

References