Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 27608..28266 Replicon plasmid pAS47-3
Accession NZ_CP061632
Organism Acinetobacter seifertii strain AS47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IC780_RS21335 Protein ID WP_000312250.1
Coordinates 27907..28266 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IC780_RS21330 Protein ID WP_001096429.1
Coordinates 27608..27907 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC780_RS21295 23667..23924 + 258 WP_000834292.1 hypothetical protein -
IC780_RS21300 23929..24501 + 573 WP_032011345.1 hypothetical protein -
IC780_RS21305 24477..24656 + 180 WP_002081921.1 hypothetical protein -
IC780_RS21310 24673..25302 + 630 WP_002081923.1 hypothetical protein -
IC780_RS21315 25342..25851 + 510 WP_032018705.1 hypothetical protein -
IC780_RS21320 25932..26486 + 555 WP_000790086.1 hypothetical protein -
IC780_RS21325 26536..27072 + 537 WP_032010581.1 hypothetical protein -
IC780_RS21330 27608..27907 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
IC780_RS21335 27907..28266 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IC780_RS21340 28467..29033 + 567 WP_031948745.1 hypothetical protein -
IC780_RS21345 29082..29312 + 231 WP_045124240.1 hypothetical protein -
IC780_RS21350 29331..30029 + 699 WP_000873188.1 hypothetical protein -
IC780_RS21355 30167..30550 + 384 WP_032018724.1 hypothetical protein -
IC780_RS21360 30617..31375 + 759 WP_001053130.1 hypothetical protein -
IC780_RS21365 31427..31762 + 336 WP_000654056.1 hypothetical protein -
IC780_RS21370 32628..32942 + 315 WP_032011240.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-82 - 1..74124 74124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T172765 WP_000312250.1 NZ_CP061632:c28266-27907 [Acinetobacter seifertii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T172765 NZ_CP079924:183644-183751 [Escherichia sp. TC-EC600-tetX4]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT172765 WP_001096429.1 NZ_CP061632:c27907-27608 [Acinetobacter seifertii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT172765 NZ_CP079924:c183596-183530 [Escherichia sp. TC-EC600-tetX4]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References