Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1388625..1389252 Replicon chromosome
Accession NZ_CP061527
Organism Shigella dysenteriae strain HNCMB 20080

Toxin (Protein)


Gene name higB Uniprot ID A0A828BKW8
Locus tag IC625_RS07255 Protein ID WP_024258354.1
Coordinates 1388923..1389252 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q32DW6
Locus tag IC625_RS07250 Protein ID WP_000147081.1
Coordinates 1388625..1388933 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC625_RS07215 1384535..1384630 + 96 Protein_1399 DUF2138 domain-containing protein -
IC625_RS07220 1384622..1384963 + 342 Protein_1400 DUF2138 family protein -
IC625_RS07225 1384960..1385520 + 561 WP_001215754.1 DUF1175 domain-containing protein -
IC625_RS07230 1385578..1386582 - 1005 Protein_1402 tyrosine-type recombinase/integrase -
IC625_RS07235 1386716..1387947 + 1232 WP_134806060.1 IS3-like element IS600 family transposase -
IC625_RS07240 1388000..1388410 + 411 WP_000814621.1 recombination protein NinB -
IC625_RS07245 1388407..1388628 + 222 WP_001254231.1 NinE family protein -
IC625_RS07250 1388625..1388933 - 309 WP_000147081.1 helix-turn-helix transcriptional regulator Antitoxin
IC625_RS07255 1388923..1389252 - 330 WP_024258354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IC625_RS07260 1389573..1390250 + 678 WP_000957540.1 phage antirepressor Ant -
IC625_RS07265 1390325..1391047 + 723 WP_001004003.1 DNA-binding protein -
IC625_RS07270 1391085..1391225 + 141 Protein_1410 HNH endonuclease -
IC625_RS07275 1391282..1391976 + 695 WP_134801589.1 IS1 family transposase -
IC625_RS07280 1391992..1392312 - 321 Protein_1412 ABC transporter substrate-binding protein ArtJ -
IC625_RS07285 1392603..1393271 - 669 WP_000464490.1 arginine ABC transporter permease ArtM -
IC625_RS07290 1393271..1393987 - 717 WP_001001693.1 arginine ABC transporter permease ArtQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1381759..1402215 20456
- inside IScluster/Tn - - 1386716..1399141 12425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12837.87 Da        Isoelectric Point: 9.9966

>T172693 WP_024258354.1 NZ_CP061527:c1389252-1388923 [Shigella dysenteriae]
MNYTIEYYSEDVRLEVDRLPLSMRARYQHLVERMKIYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIML
HSFVKKTQKTPPAERKKAETRMKEVKHDW

Download         Length: 330 bp

>T172693 NZ_CP079882:2409534-2410025 [Proteus terrae]
ATGGGAAAAGTAACAGCACCTGAGCCGTTATCAAACTCACATGAAGTGGCTGATTTTTATAGTAGTGAAAATGTATTAGA
TAACTGGATAAAACAAAGAGGTTTAAAAAACCAATTTTTAGGTGCATCCCGTACATTTGTGGTCTGTGAAAAAAATAAAA
AACGTGTTGTTGGGTACTATTCTTTAGCAACAGGTAGTGTTAACCATACTGAAGCAATGAGTCATATTCGTCGCAATATG
CCAGACCCAATACCCGTGATCATTTTAGCTAGACTTGCTGTTGATAAAACTTTTCATGGAAAAGGTCTTGGTGCCGATTT
GTTAAGAGATGCAGTTTTGCGTTGTCATCATGTAGCTGAAAACATTGGTGTTAGAGCGATTATGGTTCATGCTTTAACTG
AAAACGCAAAACATTTCTACCTTCATCATGGTTTCAAAGCTTCTTCGACTCAAGACAAAATCTTATTCTTAGCACTAAAA
AAGAAAATATAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11185.94 Da        Isoelectric Point: 8.5840

>AT172693 WP_000147081.1 NZ_CP061527:c1388933-1388625 [Shigella dysenteriae]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT172693 NZ_CP079882:2409280-2409546 [Proteus terrae]
ATGAAAGCTGATGTACAACTCAATATTCGCGCTAAAGAATCACAACGCGCACTTATTGATACTGCTGCTGAAATTCTCCA
TAAATCTCGTACTGACTTTATTCTTGAGACAGCATGCCAAGCTGCTGAAGACGTCATTTTAGACCGTAGAACCTTTAATT
TAAATGATGCTCAATATGCGGAATTTATAGAAATTATTGATGCGCCGGTTGATATTGACCCTGCTCTTGAAAAGTTATTA
ATGAGAAAACCATTATGGGAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828BKW8

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TJC1

References