Detailed information of TA system TA172672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 53983..54641
• Replicon: plasmid pCFSAN093710_2
• Accession: NZ_CP061516
• Organism: Acinetobacter baumannii strain CFSAN093710

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FQZ19_RS20150
• Protein ID: WP_000312250.1
• Coordinates: 54282..54641 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FQZ19_RS20145
• Protein ID: WP_001096429.1
• Coordinates: 53983..54282 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQZ19_RS20105	49007..50287	+	1281	WP_001093570.1	hypothetical protein	-
FQZ19_RS20110	50392..50649	+	258	WP_000834290.1	hypothetical protein	-
FQZ19_RS20115	50654..51226	+	573	WP_000443897.1	hypothetical protein	-
FQZ19_RS20120	51202..51381	+	180	WP_000387630.1	hypothetical protein	-
FQZ19_RS20125	51398..52027	+	630	WP_000701003.1	hypothetical protein	-
FQZ19_RS20130	52067..52285	+	219	WP_001043201.1	hypothetical protein	-
FQZ19_RS20135	52305..52859	+	555	WP_000790084.1	hypothetical protein	-
FQZ19_RS20140	52909..53445	+	537	WP_000731978.1	hypothetical protein	-
FQZ19_RS20145	53983..54282	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
FQZ19_RS20150	54282..54641	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FQZ19_RS20155	54842..55408	+	567	WP_000710385.1	hypothetical protein	-
FQZ19_RS20160	55457..55639	+	183	WP_000373385.1	hypothetical protein	-
FQZ19_RS20165	55706..56404	+	699	WP_000873188.1	hypothetical protein	-
FQZ19_RS20170	56543..56926	+	384	WP_000654348.1	hypothetical protein	-
FQZ19_RS20175	56993..57751	+	759	WP_001053127.1	hypothetical protein	-
FQZ19_RS20180	58806..59120	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83626	83626

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T172672 WP_000312250.1 NZ_CP061516:c54641-54282 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T172672 NZ_CP079860:1219752-1220039 [Vibrio neptunius]
ATGACTTATAAGCTTAAATTTCTACCTGCCGCCAAGAAAGAGTGGAGCAAGTTAGCTCCACCAATTCAAAGTCAGTTTAA
AAAGAAGCTTAAAGAACGCCTCGAAAATCCGCATGTTCCCGCATCTAAACTTCGCGGCTATGACTCAGTTTACAAGATCA
AGCTACGTACTGCGGGTTATCGTTTAGCCTACGAAGTGATCGACGATGAAATCGTGGTGTATGTGTTGGCTATTGGTAAA
AGAGACAAAGATGCAGTGTACAAAAAGCTAGCAACGAGGTCCTCGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT172672 WP_001096429.1 NZ_CP061516:c54282-53983 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT172672 NZ_CP079860:1219511-1219762 [Vibrio neptunius]
ATGAGACAGGTTTTAGCTGATTATTCAGCAAGTATTTCTGAGTTAAAGAAAAATCCTACCGCTTTGCTAAATGAAGCTGA
TGGTTCTGCTATTGCTATTCTGAACCACAATAAGCCAGCAGCTTATCTTGTTCCTGCGGAAACTTATGAGTTTCTGATGG
ATATGCTCGATGATTACGAGCTGGCTAAACTTGTTGAAAGTCGTCGCGGTGAGTTATCTGAAGCGGTTGAAGTAAATATC
GATGACTTATAA