Detailed information of TA system TA172663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 2243122..2243963
• Replicon: chromosome
• Accession: NZ_CP061498
• Organism: Roseicitreum antarcticum strain ZS2-28

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: H9529_RS10760
• Protein ID: WP_092890544.1
• Coordinates: 2243122..2243640 (-)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: H9529_RS10765
• Protein ID: WP_092890547.1
• Coordinates: 2243637..2243963 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9529_RS10720	2238375..2238719	-	345	WP_176847174.1	DUF1801 domain-containing protein	-
H9529_RS10725	2238806..2239666	-	861	WP_092890529.1	AraC family transcriptional regulator	-
H9529_RS10730	2240016..2240477	+	462	WP_092890532.1	GNAT family N-acetyltransferase	-
H9529_RS10735	2240580..2241032	-	453	WP_190305615.1	DMT family transporter	-
H9529_RS10740	2241042..2241575	-	534	WP_092890538.1	GNAT family N-acetyltransferase	-
H9529_RS10745	2241572..2242132	-	561	WP_092890541.1	helix-turn-helix transcriptional regulator	-
H9529_RS10750	2242449..2242703	+	255	WP_176847133.1	hypothetical protein	-
H9529_RS10755	2242649..2242897	+	249	Protein_2113	transposase family protein	-
H9529_RS10760	2243122..2243640	-	519	WP_092890544.1	type II toxin-antitoxin system YhaV family toxin	Toxin
H9529_RS10765	2243637..2243963	-	327	WP_092890547.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
H9529_RS10770	2244157..2244552	-	396	WP_190305617.1	integrase core domain-containing protein	-
H9529_RS10775	2244500..2244709	-	210	WP_092884165.1	WGR domain-containing protein	-
H9529_RS10780	2244713..2245318	-	606	WP_092884167.1	site-specific integrase	-
H9529_RS10785	2245694..2245882	+	189	WP_092884169.1	hypothetical protein	-
H9529_RS10790	2245895..2246848	+	954	WP_092884171.1	hypothetical protein	-
H9529_RS10795	2246857..2247832	+	976	Protein_2121	hypothetical protein	-
H9529_RS10800	2248010..2248234	+	225	WP_092885261.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2238375..2249620	11245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (19-155)

Antitoxin

• PrlF antitoxin (9-104)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19305.94 Da
• Isoelectric Point: 9.6088

>T172663 WP_092890544.1 NZ_CP061498:c2243640-2243122 [Roseicitreum antarcticum]
MSGDSVPAQAPLVVNGWSIYAHPLFLDQLEGLIEEVEARKARDPKSWRKKNCTKRLAAIFKLVTEAIPADPGAAAFRQGG
TLGDHRKHWFRAKFFQQYRLFYRFNSDAKVIVVAWVNDDKTLRAYGSKTDAYATFKGMLDNGNPPDNFDALLKEAAAADK
RFEASLEAVPDR

Nucleotide

• Length: 519 bp

>T172663 NZ_CP079839:c4309144-4308989 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTATCACCGTTGTAATGGCGGTGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGCATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACGGCTTACGAATCTGAGGAGTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11908.39 Da
• Isoelectric Point: 4.3209

>AT172663 WP_092890547.1 NZ_CP061498:c2243963-2243637 [Roseicitreum antarcticum]
MTALAQDVSKLTDRYQTTVPAGVRKQLKLGKGDQIRYCTEPSGRVYIEPVRAEEEDPVLGAFLDFVEADIKAHPDRIRAF
DGALHDRLAALVGDVDVDLDAPLSLEDE

Nucleotide

• Length: 327 bp

>AT172663 NZ_CP079839:4309156-4309214 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA