Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 769979..770754 Replicon chromosome
Accession NZ_CP061404
Organism Klebsiella pneumoniae strain NU-CRE055

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag HCV81_RS03830 Protein ID WP_009308645.1
Coordinates 770269..770754 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HCV81_RS03825 Protein ID WP_004150912.1
Coordinates 769979..770272 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV81_RS03805 765187..765789 - 603 WP_020802400.1 short chain dehydrogenase -
HCV81_RS03810 765887..766798 + 912 WP_049001750.1 LysR family transcriptional regulator -
HCV81_RS03815 766799..767947 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
HCV81_RS03820 767958..769334 - 1377 WP_072158501.1 cystathionine beta-synthase -
HCV81_RS03825 769979..770272 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HCV81_RS03830 770269..770754 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
HCV81_RS03835 771458..772049 + 592 Protein_754 hypothetical protein -
HCV81_RS03840 772146..772362 + 217 Protein_755 transposase -
HCV81_RS03850 773040..773753 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 772146..772298 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T172630 WP_009308645.1 NZ_CP061404:770269-770754 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T172630 NZ_CP079836:2089146-2089301 [Salmonella enterica subsp. salamae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTATCACCGTTGTAATGGCGGTGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGCATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACGGCTTACGAATCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT172630 WP_004150912.1 NZ_CP061404:769979-770272 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT172630 NZ_CP079836:c2089134-2089076 [Salmonella enterica subsp. salamae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References