Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 338807..339393 Replicon chromosome
Accession NZ_CP061404
Organism Klebsiella pneumoniae strain NU-CRE055

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HCV81_RS01565 Protein ID WP_002920800.1
Coordinates 339025..339393 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HCV81_RS01560 Protein ID WP_004174006.1
Coordinates 338807..339028 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV81_RS01540 334964..335890 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HCV81_RS01545 335887..337164 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HCV81_RS01550 337161..337928 + 768 WP_059064988.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HCV81_RS01555 337930..338643 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HCV81_RS01560 338807..339028 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HCV81_RS01565 339025..339393 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HCV81_RS01570 339664..340980 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HCV81_RS01575 341087..341974 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HCV81_RS01580 341971..342816 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HCV81_RS01585 342818..343888 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 335887..344625 8738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T172629 WP_002920800.1 NZ_CP061404:339025-339393 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T172629 NZ_CP079836:960065-960478 [Salmonella enterica subsp. salamae]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGTTGCTATTGTCGCTGGTCGTGTTCGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGGGAGATCAAGCTACTCATGGACGGACGTTTACGCTGGCAGGGGCAA
GACTGGACGCTCTTGCATCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCTGAGTCTGGACGCCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATAGTGTTACAGCAACCGATAT
CGCGCCAACACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT172629 WP_004174006.1 NZ_CP061404:338807-339028 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT172629 NZ_CP079836:959818-960084 [Salmonella enterica subsp. salamae]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGCTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References