Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6269767..6270388 Replicon chromosome
Accession NZ_CP061379
Organism Bradyrhizobium genosp. B strain BDV5040

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag IC761_RS29360 Protein ID WP_195800156.1
Coordinates 6269767..6270051 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IC761_RS29365 Protein ID WP_195800157.1
Coordinates 6270092..6270388 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC761_RS29340 6264914..6265051 + 138 WP_195800152.1 hypothetical protein -
IC761_RS29345 6265084..6266022 - 939 WP_195800153.1 GTP-binding protein -
IC761_RS29350 6266026..6267516 - 1491 WP_195800154.1 amidohydrolase family protein -
IC761_RS29355 6267892..6269022 + 1131 WP_195800155.1 hypothetical protein -
IC761_RS29360 6269767..6270051 + 285 WP_195800156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IC761_RS29365 6270092..6270388 + 297 WP_195800157.1 HigA family addiction module antidote protein Antitoxin
IC761_RS29370 6270487..6271449 - 963 WP_195800158.1 AraC family transcriptional regulator -
IC761_RS29375 6271580..6272116 + 537 WP_195800159.1 carboxymuconolactone decarboxylase family protein -
IC761_RS35750 6272221..6272478 - 258 WP_210338487.1 ATP-binding domain-containing protein -
IC761_RS29380 6272424..6272885 - 462 WP_210338488.1 NERD domain-containing protein -
IC761_RS29390 6273313..6273903 - 591 WP_195800160.1 DUF2846 domain-containing protein -
IC761_RS29395 6274018..6274362 - 345 WP_195800161.1 hypothetical protein -
IC761_RS29400 6274361..6275368 + 1008 WP_195800162.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-82)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10758.42 Da        Isoelectric Point: 9.8595

>T172529 WP_195800156.1 NZ_CP061379:6269767-6270051 [Bradyrhizobium genosp. B]
MIRSFRGKFAEPILQDRTVPKGFPADLAKVARRKLIMVDAADFLDALRSPPGNRLEALKGDLAAKHSIRINDQWRIVFRW
TETGPEDVEIVDYH

Download         Length: 285 bp

>T172529 NZ_CP079777:88395-88682 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGGTTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11048.98 Da        Isoelectric Point: 9.8803

>AT172529 WP_195800157.1 NZ_CP061379:6270092-6270388 [Bradyrhizobium genosp. B]
MAKKLPPIHPGEILREEFLVPLKLTPYAVAAALNVPRTRIERIAREEKPVTADTALRLGKFFKTGAAFWMNIQTRYDLET
AEDVLAPQIKKIASYEAV

Download         Length: 297 bp

>AT172529 NZ_CP079777:88147-88398 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References