Detailed information of TA system TA172505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 3342765..3343306
• Replicon: chromosome
• Accession: NZ_CP061369
• Organism: Komagataeibacter rhaeticus strain ENS9b

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ICJ78_RS15320
• Protein ID: WP_081749560.1
• Coordinates: 3342765..3343034 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A181CES2
• Locus tag: ICJ78_RS15325
• Protein ID: WP_061276673.1
• Coordinates: 3343031..3343306 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICJ78_RS15290	3337912..3338563	+	652	Protein_3005	hypothetical protein	-
ICJ78_RS15295	3338564..3339178	+	615	WP_039998314.1	RES family NAD+ phosphorylase	-
ICJ78_RS15300	3339467..3340240	-	774	WP_034931780.1	aromatic-ring-hydroxylating dioxygenase	-
ICJ78_RS15305	3340230..3341567	-	1338	WP_172459691.1	transposase	-
ICJ78_RS15310	3341924..3342199	-	276	Protein_3009	transposase	-
ICJ78_RS15315	3342205..3342752	-	548	Protein_3010	hypothetical protein	-
ICJ78_RS15320	3342765..3343034	-	270	WP_081749560.1	Txe/YoeB family addiction module toxin	Toxin
ICJ78_RS15325	3343031..3343306	-	276	WP_061276673.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ICJ78_RS15330	3343840..3344198	-	359	Protein_3013	IS110 family transposase	-
ICJ78_RS15335	3344211..3345161	-	951	WP_191011366.1	IS21 family transposase	-
ICJ78_RS15340	3345279..3345398	+	120	Protein_3015	IS3 family transposase	-
ICJ78_RS15345	3345479..3346078	-	600	WP_035366892.1	DUF488 domain-containing protein	-
ICJ78_RS15350	3346077..3346292	+	216	WP_061507197.1	DUF2945 domain-containing protein	-
ICJ78_RS15355	3346593..3347781	-	1189	Protein_3018	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3212035..3467854	255819

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10486.83 Da
• Isoelectric Point: 8.1012

>T172505 WP_081749560.1 NZ_CP061369:c3343034-3342765 [Komagataeibacter rhaeticus]
VKVIFHEDGWEDYLSWFQSDHAVLGKVNALIEDVRRHPFQGIGKPEPLKGQLSGWWSRRITGEHRLVYRVQGRAGEDQRI
EVAQCRFHY

Nucleotide

• Length: 270 bp

>T172505 NZ_CP079772:1230236-1231558 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10223.41 Da
• Isoelectric Point: 4.8498

>AT172505 WP_061276673.1 NZ_CP061369:c3343306-3343031 [Komagataeibacter rhaeticus]
MTCVSYTDLRQNLAHYLDEAVNSRAPIVVTRKTGKGSVVLMSEEEFSGWQETVHLLSSPRNAERLLRSIRDIEHGAATER
DLLEPQDEPSA

Nucleotide

• Length: 276 bp

>AT172505 NZ_CP079772:1229970-1230236 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A181CES2